Structure of PDB 5epi Chain N Binding Site BS01

Receptor Information
>5epi Chain N (length=756) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEYS
NKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEHP
GLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITSF
RLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKLPAKNRKGFL
IKRIPMKVKDKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIRG
FVLVVENLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGISM
TVTGDNTKWNECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIAR
LGKGFMITSKTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEEG
TASLSPGMMMGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALFV
NAKDEETCMEGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDGF
VSNFAMELPSFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQLF
IADYRYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYNL
RNLHIPEIVLKYNLMDPEYKGRLLHPQNPFVGHLSIEGIKEADITKMDYD
AVSGTHSWRTKRNRSILNTDQRNMILEEQCYAKCCNLFEACFNSASYRKP
VGQHSMLEAMAHRLRMDARLDYESGRMSKDDFEKAMAHLGEIGYIGSGSG
ENLYFQ
Ligand information
Receptor-Ligand Complex Structure
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PDB5epi Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		H32 G33 T34 Y38 M356 K365 E384 L674 N675
Binding residue
(residue number reindexed from 1)		H32 G33 T34 Y38 M356 K365 E384 L667 N668
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5epi, PDBe:5epi, PDBj:5epi
PDBsum5epi
PubMed26711008
UniProtQ5V8Y6

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