Structure of PDB 5cd4 Chain N Binding Site BS01

Receptor Information

>5cd4 Chain N (length=356) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SNFINIHVLISHSPSCLNRDDMNMQKDAIFGGKRRVRISSQSLKRAMRKS
GYYAQNIGESSLRTIHLAQLRDVLRQKLGERFDQKIIDKTLALLSGKSVD
EAEKISADAVTPWVVGEIAWFCEQVAKAEADNLDDKKLLKVLKEDIAAIR
VNLQQGVDIALSGRMATSGMMTELGKVDGAMSIAHAITTHQVDSDIDWFT
AVDDLQELGTQEFSSGVFYRYANINLAQLQENLGGASREQALEIATHVVH
MLATEVPGAKQRTYAAFNPADMVMVNFSDMPLSMANAFEKAVKAKDGFLQ
PSIQAFNQYWDRVANGYGLNGAAAQFSLSDVDPITAQVKQMPTLEQLKSW
VRNNGE

Ligand information

>5cd4 Chain X (length=61) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

auaaaccgacgguauuguucagauccuggcuugccaacaggaguuccccg
cgccagcgggg

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Receptor-Ligand Complex Structure

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Structure summary

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PDB	5cd4 Mechanism of CRISPR-RNA guided recognition of DNA targets in Escherichia coli.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	N19 R20 D22 K27 Q42 S43 K45 R46 M166
Binding residue (residue number reindexed from 1)	N18 R19 D21 K26 Q41 S42 K44 R45 M165

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0071667	DNA/RNA hybrid binding

	Biological Process
GO:0051607	defense response to virus
GO:0099048	CRISPR-cas system

	Cellular Component
GO:0032991	protein-containing complex

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Cellular Component

External links

PDB	RCSB:5cd4, PDBe:5cd4, PDBj:5cd4
PDBsum	5cd4
PubMed	26243775
UniProt	Q46899\|CASC_ECOLI CRISPR system Cascade subunit CasC (Gene Name=casC)

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