Structure of PDB 1p7h Chain N Binding Site BS01

Receptor Information
>1p7h Chain N (length=286) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSVPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPV
VQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKI
VGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRV
RLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYG
GQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEI
PEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1p7h Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa B element
Resolution2.6 Å
Binding residue
(original residue number in PDB)		R421 R430 R537 Q571 H575 G663 K664 R665 K666
Binding residue
(residue number reindexed from 1)		R29 R38 R145 Q179 H183 G271 K272 R273 K274
Binding affinityPDBbind-CN: Kd=20nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1p7h, PDBe:1p7h, PDBj:1p7h
PDBsum1p7h
PubMed12949493
UniProtQ13469|NFAC2_HUMAN Nuclear factor of activated T-cells, cytoplasmic 2 (Gene Name=NFATC2)

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