Structure of PDB 1ncc Chain N Binding Site BS01

Receptor Information
>1ncc Chain N (length=389) Species: 384509 (Influenza A virus (A/tern/Australia/G70C/1975(H11N9))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IRDFNNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPYVSCDPDECR
FYALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWS
STSCHDGKTRMSICISGPNNNASAVIWYNRRPVTEINTWARNILRTQESE
CVCHNGVCPVVFTDGSATGPAETRIYYFKEGKILKWEPLAGTAKHIEECS
CYGERAEITCTCRDNWQGSNRPVIRIDPVAMTHTSQYICSPVLTDNPRPN
DPTVGKCNDPYPGNNNNGVKGFSYLDGVNTWLGRTISRASRSGYEMLKVP
NALTDDKSKPTQGQTIVLNTDWSGYSGSFMDYWAEGECYRACFYVELIRG
RPKEDKVWWTSNSIVSMCSSTEFLGQWDWPDGAKIEYFL
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1ncc Chain N Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1ncc Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		D293 G297 D324 N347
Binding residue
(residue number reindexed from 1)		D214 G218 D245 N267
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) R292 Y406
Catalytic site (residue number reindexed from 1) R213 Y325
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1ncc, PDBe:1ncc, PDBj:1ncc
PDBsum1ncc
PubMed1522584
UniProtP03472|NRAM_I75A5 Neuraminidase (Gene Name=NA)

[Back to BioLiP]