Structure of PDB 6fsz Chain MM Binding Site BS01

Receptor Information
>6fsz Chain MM (length=978) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDLFDVFEETPVELMLADSFEQEASREVDASKGLTNSETLQVEQDGKVRL
SHQVRHQVALPPNYDYTPIAEHKRVNEARTYPFTLDPFQDTAISCIDRGE
SVLVSAHTSAGKTVVAEYAIAQSLKNKQRVIYTSPIKALSNQKYRELLAE
FGDVGLMTGDITINPDAGCLVMTTEILRSMLYRGSEVMREVAWVIFDEVH
YMRDKERGVVWEETIILLPDKVRYVFLSATIPNAMEFAEWICKIHSQPCH
IVYTNFRPTPLQHYLFPAHGDGIYLVVDEKSTFREENFQKAMASISGDIY
KIVKMIWKKKYNPVIVFSFSKRDCEELALKMSKLDFNSDDEKEALTKIFN
NAIALLPETDRELPQIKHILPLLRRGIGIHHSGLLPILKEVIEILFQEGF
LKVLFATETFSIGLNMPAKTVVFTSVRKWDGQQFRWVSGGEYIQMSGRAG
RRGLDDRGIVIMMIDEKMEPQVAKGMVKGQADRLDSAFHLGYNMILNLMR
VEGISPEFMLEHSFFQFQNVISVPVMEKKLAELKKDFDGIEVEDEENVKE
YHEIEQAIKGYREDVRQVVTHPANALSFLQPGRLVEISVNGKDNYGWGAV
VDFAKRINKRNPSAVYTDHESYIVNVVVNTMYIDSPVNLLKPFNPTLPEG
IRPAEEGEKSICAVIPITLDSIKSIGNLRLYMPKDIRASGQKETVGKSLR
EVNRRFPDGIPVLDPVKNMKIEDEDFLKLMKKIDVLNTKLSSNPLTNSMR
LEELYGKYSRKHDLHEDMKQLKRKISESQAVIQLDDLRRRKRVLRRLGFC
TPNDIIELKGRVACEISSGDELLLTELIFNGNFNELKPEQAAALLSCFAF
QERCKEAPRLKPELAEPLKAMREIAAKIAKIMKDSKIEVVEKDYVESFRH
ELMEVVYEWCRGATFTQICKMTDVYEGSLIRMFKRLEELVKELVDVANTI
GNSSLKEKMEAVLKLIHRDIVSAGSLYL
Ligand information
>6fsz Chain 2 (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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.......................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6fsz Structure of the nuclear exosome captured on a maturing preribosome.
Resolution4.6 Å
Binding residue
(original residue number in PDB)		K202 G224 T227 E240 I241 S244 M245 R272 K416 H476 S477 T502 T504 W524 G526 S913 E1033
Binding residue
(residue number reindexed from 1)		K137 G159 T162 E175 I176 S179 M180 R207 K321 H381 S382 T407 T409 W429 G431 S818 E938
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003729 mRNA binding
GO:0003824 catalytic activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008143 poly(A) binding
GO:0016491 oxidoreductase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0034458 3'-5' RNA helicase activity
Biological Process
GO:0000292 RNA fragment catabolic process
GO:0000460 maturation of 5.8S rRNA
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0006397 mRNA processing
GO:0006401 RNA catabolic process
GO:0016075 rRNA catabolic process
GO:0034475 U4 snRNA 3'-end processing
GO:0034476 U5 snRNA 3'-end processing
GO:0071028 nuclear mRNA surveillance
GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process
GO:0071038 TRAMP-dependent tRNA surveillance pathway
GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process
GO:0071051 poly(A)-dependent snoRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0031499 TRAMP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fsz, PDBe:6fsz, PDBj:6fsz
PDBsum6fsz
PubMed29519915
UniProtP47047|MTR4_YEAST ATP-dependent RNA helicase DOB1 (Gene Name=MTR4)

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