Structure of PDB 8rd8 Chain MB Binding Site BS01

Receptor Information

>8rd8 Chain MB (length=119) Species: 45610 (Psychrobacter urativorans)

MRHRKSGVKLGRTSSHRKAMFQNMTNSLFEHELIKTTLPKAKELRRVAEP
LITMAKEDSVANRRLAFSRMRSKTMVGKLFGTLGPRYQNRPGGYLRIVKC
GNRDGDNAPMAYVELVDRD

Ligand information

>8rd8 Chain Z2 (length=2705)

gucaaguaaugaagcgcacaugguggaugccuuggcagucagaggcgaug
aaagacgugacagccugcgauaagcuucggggaggcggcaauauccugug
auccggagauuucugaauggggaaacccacuuaccauaagguagguaucu
ugaagaagcgaacgaggggaagugaaacaucucaguacccuuaggaaaag
acaucaaaugagauuccccaaguagcggcgagcgaacggggagaagccga
uuaaugcuaauguagaagaacagcgugggaaagcugaccguaguagguga
uaguccuguauucgaaacauuagcguuaacauauuaaguagggcgggaca
cgagaaauccugucugaagauggggggaccauccuccaaggcuaaauacu
ccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaac
cccugugaggggagugaaauagaaccugaaaccgugugcguacaagcagu
aggagccucaauuuauuggggugacugcguaccuuuuguauaauggguca
gcgacuuauauucuguagcaagguuaaccguuuaggggagccguagggaa
accgagucuuaauagggcguaguugcaggguauagacccgaaaccgagug
aucuauccaugagcagguugaaagugccguaacaggcaccggaggaccga
acccacugucguugaaaagccaggggaugacuuguggauaggggugaaag
gcuaaucaaacucggugauagcugguucuccccgaaagcuauuuagguag
cgccucggacgaauaccauuggggguagagcacuguuucggcaccgaugc
aaacuccgaauaccgaugaguaauauccgggagacacacggcgggugcua
acguccgucguggagagggaaacaacccagaccgccagcuaaggccccaa
auuccuaguuaagugggaaacgaggugggaaggcauagacagcuaggagg
uuggcuuagaagcagccauccuuuaaagaaagcguaauagcucacuaguc
gagucggccugcgcggaagauguaacggggcucaaacuaggagccgaagc
ugcggauuugaaacuuguuuucaagugguaggggagcguuguguaagccu
gugaaggugugucguaaggcaugcuggagguaucacaagagcgaaugcug
acgugaguaacgauaaugcgagugaaaagcucgcacgccggaagaucaag
gguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcga
ggccgaaaggcguagucgaugggaaauugguuaauauuccaauacuuguu
uauagugcgauggagggacggagaagguuaugucagccuggcguugguug
uccaggugaaaggauguaggcuuacaguuuaggcaaauccggacuguagg
cugagaucugauagcaaggaaguggcaaauaccaugcuuccaggaaaagc
uucuaagcgcuauaaacgaaucguacccuaaaccgacacaggugaucagg
uagagaauaccaaggcgcuugagagaacucugcugaaggaacuaggcaaa
augguaccguaacuucgggagaagguacgcuguugauggugauaggcucc
uugagcuuucgacagucgcagauaccaggcugcugcaacuguuuauuaaa
aacacagcacucugcaaacacgaaaguggacguauagggugugaugccug
cccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuuga
ucgaagccccaguaaacggcggccguaacuauaacgguccuaagguagcg
aaauuccuugucagguaaguucugaccugcacgaauggcauaaugauggc
agcgcugucuccagcagagacucagugaaaucgaaaucgcagugaagaug
cuguguacccgcggcuagacggaaagaccccgugaaccuuuacuacagcu
uuacauugaacuuggguucuaacucagguauaacaauaccgaggacaaug
uaugguggguaguuugacuggggcggucuccuccuaaagaguaacggagg
aguacgaaggugcgcucagaacggucggaaaucguucauagaguauaaag
gcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaagu
aggucuuagugauccggugguucuguauggaagggccaucgcucaacgga
uaaaagguacucuggggauaacaggcugauaccgcccaagaguucauauc
gacggcgguguuuggcaccucgaugucggcucaucucauccuagggcuga
agcagguccuaaggguauggcuguucgccauuuaaagagguacgcgagcu
ggguuuagaacgucgugagacaguucggucccuaucuaccgugggcguug
gaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaac
cucugguguucggguugucacgccaguggcauugcccgguagcuacguuc
ggaugggauaaccgcugaaagcaucuaagcgggaagcccaccucaagauu
agauuucccuaaagagccguugaagacuacgacguugauaggcagggugu
ggaagugcagcgaugcauguagcuaaccuguacuaauugcucguuuggcu
ugacc

<<<<<<<......<<<<<<<<<<<.....[[.<<<<<<<<<<[[<<....
..<<<<<<.[..(((.>>>.....<<<<<<<..<<.)))..]..>>....
.>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<
<.>>>>.>>...<<<<<<.....<<....>>......>>>>>.>......
...<<....>>..<<<<<<.....<<.....>>....>>>>>>..((...
<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<...
..))>>>...>>>...>>>>>>>>>>>>>...........<<<<<<<<..
.......>>>>>>>>......<<<<<..<<<<>>>>>...))......]]
.>>>>>>>.>>>..............<<....>>....]].........<
<<<.....>>>>..................>>>>>>>>>>>.......<<
<<..<<<<<<<....>>>>>>>..>>>>...<............>.<<<<
<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<...
.>>..<<<<.....>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.
....<<<<<<<<<..<<<<....<<<<<......>>>>>..>...>>>..
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>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<..>>>>.>>
>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<....
..>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((..
...<<<<<<...........<<..<<<<<..<<........<<<<<.<<<
..<<<<.......>>>>..>>>........<<<......>>>..>>>>>.
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>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<.
.....<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>
>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<
<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<..
.<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<
<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((..
.>>>>>>....<<<<...<<<<.<<<<<<..<<.....>>.>>>>>>.>>
>>...>>>>.............>>>>>...>>>...>>>>.........>
>>>...>>>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<
<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<............
...<<<<<...............>>>>><<<<<<<<.<<<...<<<..>>
>...>>>.>>>>>>>>............<<<<<<<<<..<<<........
.>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<
<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>.>.
....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<..
.........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>
>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........
>>>>>..<<<<<<<.<<<<.[[......<<<<.[[<<<<..<<<<<.<<<
.<<<<<.<<<<<..>>>>>...<<<.<<<<<....>>>>>>>>....>>>
>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>
>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((
>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>
>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.........
....>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>
...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<..
....>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>
.>>....<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<
<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<
...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>
>...<<<....<<<<<...........>>>>>....>>>.>>>>......
.>>>>>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<..<<
....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>.....>>>
>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8rd8 A new family of bacterial ribosome hibernation factors
• Resolution: 2.62 Å
• Binding residue (original residue number in PDB): M1 R2 H3 R4 K5 S6 G7 V8 K9 L10 G11 R12 S14 S15 H16 R17 K18 M20 N23 S27 H31 I34 K35 T36 T37 P39 K40 K42 R45 R46 E49 P50 T53 V60 R63 R64 F67 S68 R69 R71 K73 T74 G77 R90 P91 G92 G93 R96 K99 R103 D104 G105 D106 N107 A108
• Binding residue (residue number reindexed from 1): M1 R2 H3 R4 K5 S6 G7 V8 K9 L10 G11 R12 S14 S15 H16 R17 K18 M20 N23 S27 H31 I34 K35 T36 T37 P39 K40 K42 R45 R46 E49 P50 T53 V60 R63 R64 F67 S68 R69 R71 K73 T74 G77 R90 P91 G92 G93 R96 K99 R103 D104 G105 D106 N107 A108

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8rd8, PDBe:8rd8, PDBj:8rd8
• PDBsum: 8rd8
• PubMed: 38355796
• UniProt: A0A0M4U611