Structure of PDB 7qep Chain M8 Binding Site BS01

Receptor Information

>7qep Chain M8 (length=186) Species: 284813 (Encephalitozoon cuniculi GB-M1)

YFTSAMKYTRLPPSATLSRKEPRSKNIYLRALSDFYTKVASNSSVLAIKK
ISKRLKMSKSDRQPVKISKIVSEIGESKDKVAVVVAKVLDDDEVMVIPAV
KVVALQWSKGVKEKIERYGGTIGTLDQLFELCPNMDDICLVSTNKFSRRS
AKFWGPAPGEKGSTTYPRANQKCHNREKRIMMRGRK

Ligand information

>7qep Chain 1 (length=2319)

ucucuguucacgggauugauuggcauuagcggcgaugaaggacgugcagg
aggacgauaugcguuguuguugugacggugucugaauugugugcggugug
cacggggaccccuuggacuuaagcauaucaguaaagggaggagaagaaac
caaaugggauugccugaguagcggcgagugaaauggcaugagccugugug
guaacugcguggcggguuguguuuguggcagcagcggcgagugcgauuga
auucggaugcggagagggcgaugugccuguaggcgcggcggcuuuuuuug
ugaguaguguugcuugguagugcagcgcgaaugcggugguggaugcaccg
aaggcuaaauauggcugaugaccgauagcggauaaguagagugauugaag
ugugaaaaggaggaugaugagaaaugaaagugaauggagugaauggggga
uguucccgcccgucuugaaacacggaccaaggagacgacggcaggauugu
uuuccgagaggggaggaugcugcggucggacccgaaagauggugagcuau
guguguguugauugaagggaugcgaaaguguucuggaggaucuaagccgu
ucugacgugcaacucgauggcaugacaugugcauaggggcgaaagaccaa
acgaaccaucugguagcugguucccucugaaaugucucucaggacagcgg
cgacggguguaagauguuguaaagcacuaaugcgcugcguuaaacuuuga
agaugucuuuuaaguuguugccagugggcauacugugguaagcauggugu
gcgagaagggaugaaccuuuaagcgggcuaaggagucuuaugcaagguga
auccggcggccugauuuugacagccgaauugggcggcggagaaaauggaa
gggauugaauugcauuccgaugccugcgggggaguaucugaguaaggggg
cgguaucguucugcugaagguccugcgugagcggggguggaggggcgaua
ugugcagaucuugguagcaguaacaaggaaaugauuugcgcuggacgagg
guucccuguggcaggggugaaucgacuguggauacggaggugcauugaua
guuguguguauugcggcugggaggcgacuuggcugugacggaugggggcg
gcccuguccaggauagcagaacuggaugucugcugcggauuguuaugaug
cgaagcagcgaugggcgagccuguuccgaugaaaaagaggcugcuuuguc
guaccuagaccgcaucugguguccacuguuugccgcggaaguguuuugug
caagggccguaagggaagucggcaagauugauguguaacuucgggagaag
gauuggcucuagcgugcuagaacuguuuguuguggggaaucugacuguuu
acuaaaaacauagcuuuguguguggacgcaaagugaauucugcccagugc
acuuuuaguuacggccuguugggcuaagcgaguguaaacggcgggaguaa
cuaugacucucuuaagguagccaaaugccucgucauguaauuagugacgc
gcaugaauggagcaacgagauucccacugucccuacggccugucuuguga
accuacagccaagggaacgggcuugggcugaucagcggggaaagaagacc
cuguugagcuugacucuagcaugugugaagugcugggugcccagugcuuu
guggauggauguggggaguuuggcuggggcggcacgacugcuaaagacua
acgcagacguccuaaggcgggcucagcggggaaggaaaccacgcguggag
cacaagggcacaagccugcuugagacuguuccuauugcgggacuguuugg
gggaaacccuggccuagagaucccauguccuauugugcgugggacauggg
ugacagaaaaguuaccacagggauaacuggcuuguagcagccgagcgacc
auagcgacgcugcuuuuugauucuucgaugucggcucuuccuaucaucgc
gaagcagagauugcgaaguguuggauuguucacccaccaacagggaacgu
gagcuggguuuagaccgucgugagacagguuaguuuuacccuacugugug
gacugugcagcagaucuugauaguacgagaggaacucuugauugcgaccu
cugguggagcggcgugccugcuggcugcugcggagcuacgucgggaguau
aauggcugaaggccucuaagccugaagaccgacugcgcgguguguguggc
ggaagacgaccgcugugugugcaagcugugcggauggaggaggauuccga
cauuuugaggcugugcauu

[<<<<<<<<<<.......[..<<<<<<<<<..<......<<<<<<.....
...>>>.....<<<<<......>>>>>...>>>.....<<<<<<...>>>
>>>>....<<<<<<.....<......>......>>>>>.>.........<
<....>>...<<<<......<<.....>>.....>>>>...<<<......
....<<<<...>>>>...........<<<.<<.<<<.<.....<<<....
..>>>..((......<<<.....))>>>...>.>>>.>>.>>>.......
......<<<<<<<........>>>>>>>.....<<<<<..<.<<<>>>>>
..>>>........>>>>>>>.>>...............<<....>>....
]............................>>>>>>>>>>....<<<<...
....>>>>.<<<<........>>>><<<<<<....<<<<.<<<<.<<<..
...<<....>>....>>>.>>>>.>>>>..<<.<...<<<<<<.....<<
<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..
<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>..
....>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<
<<<<<....<<<<<<<<<...<<<...<<<<<<<.>>>>>>>..>.>>..
.>>>>>>>..>>...>>>>>>>.>>..<<<<<<<<<<.....>>>>>>>>
>>...<<<<......>>>>...<<<<<<...<<<.(....<<<<<.....
.<<<<...<<<<<<<............>>>>>>>..>>>>..........
.).......>>>>>.>>>...>>>>>>..<<<....>>>.....>>>>>>
<.<<<<<<<<<<......<.<<<<<<....>>>>>>.>...>>>>>>>>>
>..>.....>>>>>><<.....<<<<.<<<....>>><<<.<<<<<<.<<
...<<<<<<.>>>>>>....((<<<<<<......>>....<<<<......
..>>>>.))...<<<<<...<<<....>>>.........<<<<<<<....
<<<<<<<<<<<...((((...>>>>>>><.<<<<<<...<<.....>>..
....>>>>>>>.>>>>...>>>>>>>.............>>>>>...>>>
>..>>....<<......>>>>>>>><<<<.....>>>>...>>>......
...<<<<<<<<.<<.........<.....<<<.<....<<..>>.....>
.>>><<.<<<<<<..>>>>>>.>>..........<<<<<<<<<..<<<..
.......>>>..<<<<<<<........>>>>>>>...<<..<<<..<<<<
<<<<...<<<..<<<<<...>>>>>.>>>>>>>>>..>>>>><<<<<<..
.....>>>>>>........<...........<<<<<.......>>>>>..
...>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>...>>>>..
..>>....<<<<<........>>>>>....].<<<..<<<.<<......<
<<<.<<<<<<..<<<<<.<<<<.<<..<<<<<<<<<<..>>>>>>>>>>.
.....>>.>>>>..>>>>>...<<<.....>>>..<.<<<<.........
..>>>>.>..<<...<<<<<<<...<<<.<<.......>>.>>>.....<
<...(((>>....>>>>>>>...<<<.<<<<<......>>>>>.>>>..<
<<....>>>.>>))).......<<<<<<<<<..>>>.>..>>>>>>>>>.
.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<....
...>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<<<<<<
<<........>>>>>..>>>.<<<.........>>>.....>>>>>..>.
..>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>....
.<<<<<<<<<..<<<<..<<...............>>..>>>>.<<<<..
..<<<...<<<<<<.<<.)))).>>>>>>>>...>>>..>>>>...<<.<
...<<<<...........>>>>....>>>...>>>>>>>>>......<<<
<<.......>>>>>....<<<<<<<<<.....<<<<..<<<....>>>..
>>>>....>>>>.>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qep Adaptation to genome decay in the structure of the smallest eukaryotic ribosome
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): M7 Y9 R11 P14 S15 S25 S59 K60 K67 K88 L90 D91 D93 E94 S109 R149 R150 S151 W155 K162 R169 K179 R184 K187
• Binding residue (residue number reindexed from 1): M6 Y8 R10 P13 S14 S24 S58 K59 K66 K87 L89 D90 D92 E93 S108 R148 R149 S150 W154 K161 R168 K178 R183 K186

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7qep, PDBe:7qep, PDBj:7qep
• PDBsum: 7qep
• UniProt: Q8SS76