Structure of PDB 7ls1 Chain M3 Binding Site BS01

Receptor Information
>7ls1 Chain M3 (length=122) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VMDVNTALQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDEPM
YVKLVEALLAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRKVVGCSCVV
VKDYGKESQAKDVIEEYFKCKK
Ligand information
>7ls1 Chain m2 (length=1723) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugaccccccuucccggggggg
gaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgca
cgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuu
cgaugguagucgccgugccuaccauggugaccacgggugacggggaauca
ggguucgauuccggagagggagccugagaaacggcuaccacauccaagga
aggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacg
aaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucc
acuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagc
agccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguua
aaaagcucguaguuggaucuugggagcgggcguccccgcccucucggcgg
ggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccga
gccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuau
uuuguugguuuucggaacugaggccaugauuaagagggacggccgggggc
auucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacgga
ccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaag
ucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacga
ugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuu
ccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcug
aaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggc
uuaauuugacucaacacgggaaaccucacccggcccggacacggacagga
uugacagauugauagcucuuucucgauuccgugggugguggugcauggcc
guucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgag
acucuggcaugcuaacuaguuacgcgacccccgagcggucggcguccccc
aacuucuuagagggacaaguggcguucagccacccgagauugagcaauaa
caggucugugaugcccuuagauguccggggcugcacgcgcgcuacacuga
cuggcucagcgugugccuacccugcgccggcaggcgcggguaacccguug
aaccccauucgugauggggaucggggauugcaauuauuccccaugaacga
ggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugc
ccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugagg
cccucggaucggccccgccggggugcccuggcggagcgcugagaagacgg
ucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguag
gugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<......<<..<......<<<.
<<<........<<....<<..........>>...>>.........<<...
.....<<<.<..........<<<...........<<.....<<.......
......>>......>>.........<<<<<..<<<<<<<....>>>>>>>
.>.>>>><<..<<<<<...<......>..>>>>>......>>....<<<.
<<<<......>>>>>>>.....>>>.......>.>>>.<<<....<<<..
.....<<<<.........>>>.>..>>>......>>>...<<<.<<<<..
..>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>
.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>
>.......<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..
<...........>..>>.........<<<<<.((...<.<<<<.....<<
..))>>.......>>>>>>>>>>...>>>>>.>>>.........<.<((.
....<.<<...<<<..........................<<.<......
......>>>....<<<<<.<.......<<...<.......>..<<.....
.....>>...>>......>.>>>..>>.........<.<..<<<<<<<..
.............>>>>>>>..>.>..........<<<<<.<.<...<<<
<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>..
.....<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<
<<<<<<...<...<<<<.........>>>>...>>>>>>>>.........
.<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>.
...<<.))>>...>>.....>>>.>.>.<<.......<<<<....>>>>.
....>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<
......<<........>>..........<<<<<.<....<<<<<<.....
..<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<
<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>...
.<<<...<...<<<...<<<<<<<<<<<<.......>>>>.>>>>.....
>>>>...>>>..>.....<<<<<.....>>>>>........>>>....>>
>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<
.<<<........<.......<<<<<<<<....>>>>>>>>....>.....
....>>>.>>............<<<<<..........>>>>>........
...>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>
>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<...<
<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>
>...>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<
<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ls1 Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		I35 R36 E37 K40 D57 E58 L91 V104 C106 S107
Binding residue
(residue number reindexed from 1)		I25 R26 E27 K30 D47 E48 L81 V94 C96 S97
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
GO:0140236 translation at presynapse
GO:0140242 translation at postsynapse
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0098793 presynapse
GO:0098794 postsynapse
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ls1, PDBe:7ls1, PDBj:7ls1
PDBsum7ls1
PubMed34815424
UniProtP63323|RS12_MOUSE Small ribosomal subunit protein eS12 (Gene Name=Rps12)

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