Structure of PDB 7qep Chain M1 Binding Site BS01

Receptor Information

>7qep Chain M1 (length=167) Species: 284813 (Encephalitozoon cuniculi GB-M1)

NPMREISIKKLSIHICARESGAKLDRAAKVLEQLTGQKPVTSKARMTIRN
FGIRRNEKIAVHVNVSGKKAYELLNTALRVKEYELKESCFSNNGCFGFGI
EEHIDLGLKYDPNIGIFGMDFFVILARPGDRVSKRKRCKSRVGNKQRVYA
EDAKKWFVENFEGVLVE

Ligand information

>7qep Chain 1 (length=2319)

ucucuguucacgggauugauuggcauuagcggcgaugaaggacgugcagg
aggacgauaugcguuguuguugugacggugucugaauugugugcggugug
cacggggaccccuuggacuuaagcauaucaguaaagggaggagaagaaac
caaaugggauugccugaguagcggcgagugaaauggcaugagccugugug
guaacugcguggcggguuguguuuguggcagcagcggcgagugcgauuga
auucggaugcggagagggcgaugugccuguaggcgcggcggcuuuuuuug
ugaguaguguugcuugguagugcagcgcgaaugcggugguggaugcaccg
aaggcuaaauauggcugaugaccgauagcggauaaguagagugauugaag
ugugaaaaggaggaugaugagaaaugaaagugaauggagugaauggggga
uguucccgcccgucuugaaacacggaccaaggagacgacggcaggauugu
uuuccgagaggggaggaugcugcggucggacccgaaagauggugagcuau
guguguguugauugaagggaugcgaaaguguucuggaggaucuaagccgu
ucugacgugcaacucgauggcaugacaugugcauaggggcgaaagaccaa
acgaaccaucugguagcugguucccucugaaaugucucucaggacagcgg
cgacggguguaagauguuguaaagcacuaaugcgcugcguuaaacuuuga
agaugucuuuuaaguuguugccagugggcauacugugguaagcauggugu
gcgagaagggaugaaccuuuaagcgggcuaaggagucuuaugcaagguga
auccggcggccugauuuugacagccgaauugggcggcggagaaaauggaa
gggauugaauugcauuccgaugccugcgggggaguaucugaguaaggggg
cgguaucguucugcugaagguccugcgugagcggggguggaggggcgaua
ugugcagaucuugguagcaguaacaaggaaaugauuugcgcuggacgagg
guucccuguggcaggggugaaucgacuguggauacggaggugcauugaua
guuguguguauugcggcugggaggcgacuuggcugugacggaugggggcg
gcccuguccaggauagcagaacuggaugucugcugcggauuguuaugaug
cgaagcagcgaugggcgagccuguuccgaugaaaaagaggcugcuuuguc
guaccuagaccgcaucugguguccacuguuugccgcggaaguguuuugug
caagggccguaagggaagucggcaagauugauguguaacuucgggagaag
gauuggcucuagcgugcuagaacuguuuguuguggggaaucugacuguuu
acuaaaaacauagcuuuguguguggacgcaaagugaauucugcccagugc
acuuuuaguuacggccuguugggcuaagcgaguguaaacggcgggaguaa
cuaugacucucuuaagguagccaaaugccucgucauguaauuagugacgc
gcaugaauggagcaacgagauucccacugucccuacggccugucuuguga
accuacagccaagggaacgggcuugggcugaucagcggggaaagaagacc
cuguugagcuugacucuagcaugugugaagugcugggugcccagugcuuu
guggauggauguggggaguuuggcuggggcggcacgacugcuaaagacua
acgcagacguccuaaggcgggcucagcggggaaggaaaccacgcguggag
cacaagggcacaagccugcuugagacuguuccuauugcgggacuguuugg
gggaaacccuggccuagagaucccauguccuauugugcgugggacauggg
ugacagaaaaguuaccacagggauaacuggcuuguagcagccgagcgacc
auagcgacgcugcuuuuugauucuucgaugucggcucuuccuaucaucgc
gaagcagagauugcgaaguguuggauuguucacccaccaacagggaacgu
gagcuggguuuagaccgucgugagacagguuaguuuuacccuacugugug
gacugugcagcagaucuugauaguacgagaggaacucuugauugcgaccu
cugguggagcggcgugccugcuggcugcugcggagcuacgucgggaguau
aauggcugaaggccucuaagccugaagaccgacugcgcgguguguguggc
ggaagacgaccgcugugugugcaagcugugcggauggaggaggauuccga
cauuuugaggcugugcauu

[<<<<<<<<<<.......[..<<<<<<<<<..<......<<<<<<.....
...>>>.....<<<<<......>>>>>...>>>.....<<<<<<...>>>
>>>>....<<<<<<.....<......>......>>>>>.>.........<
<....>>...<<<<......<<.....>>.....>>>>...<<<......
....<<<<...>>>>...........<<<.<<.<<<.<.....<<<....
..>>>..((......<<<.....))>>>...>.>>>.>>.>>>.......
......<<<<<<<........>>>>>>>.....<<<<<..<.<<<>>>>>
..>>>........>>>>>>>.>>...............<<....>>....
]............................>>>>>>>>>>....<<<<...
....>>>>.<<<<........>>>><<<<<<....<<<<.<<<<.<<<..
...<<....>>....>>>.>>>>.>>>>..<<.<...<<<<<<.....<<
<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..
<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>..
....>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<
<<<<<....<<<<<<<<<...<<<...<<<<<<<.>>>>>>>..>.>>..
.>>>>>>>..>>...>>>>>>>.>>..<<<<<<<<<<.....>>>>>>>>
>>...<<<<......>>>>...<<<<<<...<<<.(....<<<<<.....
.<<<<...<<<<<<<............>>>>>>>..>>>>..........
.).......>>>>>.>>>...>>>>>>..<<<....>>>.....>>>>>>
<.<<<<<<<<<<......<.<<<<<<....>>>>>>.>...>>>>>>>>>
>..>.....>>>>>><<.....<<<<.<<<....>>><<<.<<<<<<.<<
...<<<<<<.>>>>>>....((<<<<<<......>>....<<<<......
..>>>>.))...<<<<<...<<<....>>>.........<<<<<<<....
<<<<<<<<<<<...((((...>>>>>>><.<<<<<<...<<.....>>..
....>>>>>>>.>>>>...>>>>>>>.............>>>>>...>>>
>..>>....<<......>>>>>>>><<<<.....>>>>...>>>......
...<<<<<<<<.<<.........<.....<<<.<....<<..>>.....>
.>>><<.<<<<<<..>>>>>>.>>..........<<<<<<<<<..<<<..
.......>>>..<<<<<<<........>>>>>>>...<<..<<<..<<<<
<<<<...<<<..<<<<<...>>>>>.>>>>>>>>>..>>>>><<<<<<..
.....>>>>>>........<...........<<<<<.......>>>>>..
...>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>...>>>>..
..>>....<<<<<........>>>>>....].<<<..<<<.<<......<
<<<.<<<<<<..<<<<<.<<<<.<<..<<<<<<<<<<..>>>>>>>>>>.
.....>>.>>>>..>>>>>...<<<.....>>>..<.<<<<.........
..>>>>.>..<<...<<<<<<<...<<<.<<.......>>.>>>.....<
<...(((>>....>>>>>>>...<<<.<<<<<......>>>>>.>>>..<
<<....>>>.>>))).......<<<<<<<<<..>>>.>..>>>>>>>>>.
.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<....
...>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<<<<<<
<<........>>>>>..>>>.<<<.........>>>.....>>>>>..>.
..>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>....
.<<<<<<<<<..<<<<..<<...............>>..>>>>.<<<<..
..<<<...<<<<<<.<<.)))).>>>>>>>>...>>>..>>>>...<<.<
...<<<<...........>>>>....>>>...>>>>>>>>>......<<<
<<.......>>>>>....<<<<<<<<<.....<<<<..<<<....>>>..
>>>>....>>>>.>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qep Adaptation to genome decay in the structure of the smallest eukaryotic ribosome
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): H20 C22 R24 R51 F57 C95 S97 N99 G103 G105 E107 G124 M125 D126 F128
• Binding residue (residue number reindexed from 1): H14 C16 R18 R45 F51 C89 S91 N93 G97 G99 E101 G118 M119 D120 F122

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7qep, PDBe:7qep, PDBj:7qep
• PDBsum: 7qep
• UniProt: Q8SSG9|RL11_ENCCU Large ribosomal subunit protein uL5 (Gene Name=RPL11)