Structure of PDB 8tvy Chain M Binding Site BS01

Receptor Information
>8tvy Chain M (length=558) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDEEEENDDKILKELEDLRFRGQPGEAKDDGDELYYQERLKKWVKQRSCG
SQRSSDLPEWRRPHPNIPDAKLNSQFKIPGEIYSLLFNYQKTCVQWLYEL
YQQNCGGIIGDEMGLGKTIQVIAFIAALHHSGLLTGPVLIVCPATVMKQW
CNEFQHWWPPLRTVILHSMGSGMASDHILITTYVGLRIHSDKLLKVKWQY
AVLDEGHKIRNPDSEISLTCKKLKTHNRIILSGTPIQNNLTELWSLFDFI
FPGKLGTLPVFQQQFVIPINIGGYANATNIQVQTGYKCAVALRDLISPYL
LRRVKADVAKDLPQKKEMVLFCKLTKYQRSKYLEFLHSSDLNQIQNGKRN
VLFGIDILRKICNHPDLLDRDTKRHNPDYGDPKRSGKMQVVKQLLLLWHK
QGYKALLFTQSRQMLDILEEFISTKDPDLSHLNYLRMDGTTNIKGRQSLV
DRFNNESFDVFLLTTRVGGLGVNLTGANRIIIFDPDWNPSTDMQARERAW
RIGQKREVSIYRLMVGGSIEEKIYHRQIFKQFLTNRILTDPKQKRFFKIH
ELHDLFSL
Ligand information
>8tvy Chain N (length=47) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ctagttgatctcatatttcattcctactcaggagaaggagcagagcg
Receptor-Ligand Complex Structure
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PDB8tvy Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K253 R452 N476 S479 E480 N504 N535 K709 W752 F794 L798 I814 H815 H818
Binding residue
(residue number reindexed from 1)		K42 R187 N211 S214 E215 N239 N270 K444 W487 F529 L533 I549 H550 H553
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006974 DNA damage response
GO:0061635 regulation of protein complex stability
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tvy, PDBe:8tvy, PDBj:8tvy
PDBsum8tvy
PubMed38194460
UniProtP40352|RAD26_YEAST DNA repair and recombination protein RAD26 (Gene Name=RAD26)

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