Structure of PDB 8qcf Chain M Binding Site BS01

Receptor Information
>8qcf Chain M (length=657) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EWAHVVDNFDELIPNPARSWPFELDTFQKEAVYHLEQGDSVFVAAHTSAG
KTVVAEYAIAMAHRNMTKTIYTSPIKALSNQKFRDFKETFDDVNIGLITG
DVQINPDANCLIMTTEILRSMLYRGADLIRDVEFVIFDQVHYVNDQDRGV
VWEEVIIMLPQHVKFILLSATVPNTYEFANWIGRTKQKNIYVISTPKRPV
PLEINIWAKKELIPVINQNSEFLEANFRKHKEILNDGPSKKTWPEIVNYL
RKRELLPMVVFVFSKKRCEEYADWLEGINFCNNKEKSQIHMFIEKSITRL
KKEDRDLPQILKTRSLLERGIAVHHGGLLPIVKELIEILFSKGFIKVLFA
TETFAMGLNLPTRTVIFSSIRKHDGNGLRELTPGEFTQMAGRAGRRGLDS
TGTVIVMAYNSPLSIATFKEVTMGVPTRLQSQFRLTYNMILNLLRIEALR
VEEMIKYLLPDYEKRLAVLKDTEFIDQNHNVLLKGRVACEINSGYELVLT
ELILDNFLGSFEPEEIVALLSVFVYEGKTREEEPPIVTPRLAKGKQRIEE
IYKKMLCVFNTHQIPLTQDEAEFLDRKRFAMMNVVYEWARGLSFKEIMEM
SPEAEGTVVRVITWLDEICREVKTASIIIGNSTLHMKMSRAQELIKRDIV
FAASLYL
Ligand information
>8qcf Chain N (length=34) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
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PDB8qcf Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		T722 E723 T724 H744 D745 G746 W997 E1000 R1003
Binding residue
(residue number reindexed from 1)		T351 E352 T353 H373 D374 G375 W614 E617 R620
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006401 RNA catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8qcf, PDBe:8qcf, PDBj:8qcf
PDBsum8qcf
PubMed37879335
UniProtP35207|SKI2_YEAST Antiviral helicase SKI2 (Gene Name=SKI2)

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