Structure of PDB 8p4a Chain M Binding Site BS01

Receptor Information
>8p4a Chain M (length=507) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYL
KSLKVKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTE
TFIRLCERFNERNPPELIGVHSTHGFNRTGFLICAFLVEKMDWSIEAAVA
TFAQARPPGIYKGDYLKELFRRYGDIEEGAIFLEGVTVKGVTQVTTQPKL
GEVQQKCHQFCGWEGSGFPGAQPVSMDKQNIKLLDLKPYKVSWKADGTRY
MMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLRMHLSNTLLDGEMIIDR
VNGQAVPRYLIYDIIKFNSQPVGDCDFNVRLQCIEREIISPRHEKMKTGL
IDKTQEPFSVRNKPFFDICTSRKLLAKEVSHEMDGLIFQPTGKYKPGRCD
DILKWKNSVDFRLKITRMGGEGLLPQNVGLLYVGGYERPFAQIKVTKELK
QYDNKIIECKFENNSWVFMRQRTDKSFPNAYNTAMAVCNSISNPVTKEML
FEFIDRC
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8p4a Structural insights into human co-transcriptional capping.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		K5 S71 R72 H94
Binding residue
(residue number reindexed from 1)		K1 S67 R68 H90
Enzymatic activity
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.6.1.74: mRNA 5'-phosphatase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004484 mRNA guanylyltransferase activity
GO:0004651 polynucleotide 5'-phosphatase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0008192 RNA guanylyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0050355 inorganic triphosphate phosphatase activity
GO:0140818 mRNA 5'-triphosphate monophosphatase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006370 7-methylguanosine mRNA capping
GO:0006396 RNA processing
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8p4a, PDBe:8p4a, PDBj:8p4a
PDBsum8p4a
PubMed37369200
UniProtO60942|MCE1_HUMAN mRNA-capping enzyme (Gene Name=RNGTT)

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