Structure of PDB 8osl Chain M Binding Site BS01

Receptor Information

>8osl Chain M (length=314) Species: 10090 (Mus musculus)

AKRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRK
HKETTAQSLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLP
SDLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSKNQLEFCCH
MLRGTIDPKEPSTYEYVRFIGNFKSLTRVCFVATVRLATPQFIKEMCTVE
EPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLEN
LAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIV
CTHTVVSYAEVRAE

Ligand information

>8osl Chain I (length=147)

cccccaccccgactttgttcctggatccgttatgcaacccaagcttcaac
tctgggtttgtagtgtgtccaggaccttgaggggagagggactttgaaag
ccacgcctttcctccagcctcacccttcacgtttgtggtccacgtgc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8osl Cooperation between bHLH transcription factors and histones for DNA access.
• Resolution: 4.9 Å
• Binding residue (original residue number in PDB): K44 D69 K70
• Binding residue (residue number reindexed from 1): K11 D36 K37

Enzymatic activity

• Enzyme Commision number: 2.3.1.48: histone acetyltransferase.

Gene Ontology

Molecular Function

• GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
• GO:0003700 DNA-binding transcription factor activity
• GO:0046983 protein dimerization activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0032922 circadian regulation of gene expression

Cellular Component

• GO:0005634 nucleus
• GO:0005667 transcription regulator complex
• GO:0005737 cytoplasm

External links

• PDB: RCSB:8osl, PDBe:8osl, PDBj:8osl
• PDBsum: 8osl
• PubMed: 37407816
• UniProt: O08785|CLOCK_MOUSE Circadian locomoter output cycles protein kaput (Gene Name=Clock)