Structure of PDB 8dh3 Chain M Binding Site BS01

Receptor Information
>8dh3 Chain M (length=775) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NTINIAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARF
RKMFERQLKAGEVADNAAAKPLITTLLPKMIARINDWFEEVKAKRAYITI
KTTLACLTSADNTTVQAVASAIGRAIEDEARFGRIRDLEAKHFKKNVEEQ
LNKRVGHVYKKAFMSWHKEDSIHVGVRCIEMLIESETIELAPEYAEAIAT
RAGALAGISPMFQPCVVPPKPWTGITGGGYWANGRRPLALVRTHSKKALM
RYEDVYMPEVYKAINIAQNTAWKINKKVLAVANVITKWKHCPVEDIPEAL
TAWKRAAAAVYRKDKARKSRRISLEFMLEQANKFANHKAIWFPYNMDWRG
RVYAVSMFNPQGNDMTKGLLTLAKGKPIGKEGYYWLKIHGANCAGVDKVP
FPERIKFIEENHENIMACAKSPLENTWWAEQDSPFCFLAFCFEYAGVQHH
GLSYNCSLPLAFDGSCSGIQHFSAMLRDEVGGRAVNLLPSETVQDIYGIV
AKKVNEILQADAINGTDNEVKLGTKALAGQWLAYGVTRSVTKRSVMTLAY
GSKEFGFRQQVLEDTIQPAIDSGKGLMFTQPNQAAGYMAKLIWESVSVTV
VAAVEAMNWLKSAAKLLAAEVKDKKTGEILRKRCAVHWVTPDGFPVWQEY
KKPIQTRLDSEIDAHKQESGIAPNFVHSQDGSHLRKTVVWAHEKYGIESF
ALIHDSFGTIPADAANLFKAVRETMVDTYESCDVLADFYDQFADQLHESQ
LDKMPALPAKGNLNLRDILESDFAF
Ligand information
Receptor-Ligand Complex Structure
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PDB8dh3 Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R50 R57 R298 H300 R423 Y427 T636 Y639 G640 S641 F644 Q649 Y739 H772 K773 P780
Binding residue
(residue number reindexed from 1)		R49 R56 R242 H244 R349 Y353 T547 Y550 G551 S552 F555 Q560 Y650 H665 K666 P673
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dh3, PDBe:8dh3, PDBj:8dh3
PDBsum8dh3
PubMed36635281
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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