Structure of PDB 7uvx Chain M Binding Site BS01

Receptor Information

>7uvx Chain M (length=119) Species: 480119 (Acinetobacter baumannii AB0057)

MRHRNSGVKLGRTSSHRKAMFENLANSLFEHELIKTTLPKAKELRRVAEP
LITLAKNDTVANRRLAFARTRNAATVGKLFTVLGPRYKERNGGYLRVLKA
GFRAGDAAPMAYVELVDRE

Ligand information

>7uvx Chain A (length=2715)

gucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaug
aaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuu
gauccggagaugucugaaugggggaacccaccuacuuuaagguagguauu
gcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacauc
ucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcga
gcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucu
gggaagugcgaacguagagggugauauucccguacacgaaagggcacaca
uaaugaugacgaguagggcgaggcacgugaaaccuugucugaauaugggg
ggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccagu
accgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauc
cugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugc
guaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaac
cguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugc
uggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguu
ggguaacacuaacuggaggaccgaacccacugucguugaaaagccagggg
augacuuguggauaggggugaaaggcuaaucaagccuggugauagcuggu
ucuccccgaaagcuauuuagguagcgccucggacgaauaccauagggggu
agagcacuguuucggcaccgaugcaaacuccgaauaccuaugaguacuau
ccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaau
ccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugu
gggaaggcauagacagcuauagucgagucggccugcgcggaagauguaac
ggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugg
uaggggagcguucuguaagccgaugaagguguguugagaagcaugcugga
gguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaa
acccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcug
ggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaau
gguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggc
uaaaucagccuggcguugguuguccaggugaaaggauguaggcauguauc
uuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguacu
ugugcagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuu
caguuacacaggaaucguacccgaaaccgacacagguggucaggucgagu
agaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaauggua
ccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuucc
ugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaa
acauagcacucugcaaacacgaaaguggacguauagggugugaugccugc
ccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugau
cgaagccccaguaaacggcggccgguccuaagguagcgaaauuccuuguc
ggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucucc
agcagaggcucagugaaaucgaaaucgcugugaagaugcaguguacccgc
ggcuagacggaaagaccccgugaaccuuuacugcagcuugacacugaacu
uugagguucuaacucugucccgugauccgggacgaggaccgugucuggug
gguaguuugacuggggcggucuccuccuaaagaguaacggaggaguacga
aggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaag
cgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuu
agugauccggugguucuguauggaagggccaucgcucaacggauaaaagg
uacucuggggauaacaggcugauaccgcccaagaguucauaucgacggcg
guguuuggcaccucgaugucggcucaucucauccuggggcugaagcaggu
cccaaggguauggcuguucgccauuuaaagagguacgcgagcuggguuua
gaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuu
gagaggaucugcuccuaguacgagaggaccagaguggacgaaccucuggu
guaccgguugugacgccagucgcaucgccggguagcuauguucggaaggg
auaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuuc
ccuaggacuuuauguccucuaaagagccguucgagacuaggacguugaua
gguuggauguggaagcauagugauaugugaagcugaccaauacuaauugc
ucgugaggcuugacu

<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<....
..<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>...
..>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<
<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>
......>>>>>.>.........<<<..>>>...<<<<<.....<<.....
>>....>>>>>...<<<......<<<<<<<<<<<<<<.<<<...<<<.<.
.....>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>
>>>>...........<<<<<<<<.........>>>>>>>>......<<<<
<..<<<<>>>>>..>>>......]].>>>>>>>.]]..............
.<<....>>....]].........<<<<.....>>>>.............
.....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>
...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<
<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>
>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<
<<......>>>>>>.>...>>>...<<<.<<<.<........>.>>>>>>
....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>.
.<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<....
.<<<...<<<.<<<<..>>>>.>>>..>>.>.....>>>>>>.>>>...>
>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>
>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<
<<<..<<........<<<..>>>....>>..>>>>>.>>...........
)))......>>>>>>.>>>...>>>>>>><<<<<<<<...>>>>>>>>..
..>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...
>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<......
.>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>
>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<
<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<
..<<<<<<<<<<<...((((...>>>>>>....<<<<...<<<<.<<<<<
<..<<.....>>.>>>>>>....>>>>...>>>>........<<<<<...
...>>>>>....>>>>>...>>>...>>>>.........>>>>...>>..
..>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<....
.>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<
<<.....<..>......>>>>><<<<<<<<<<<<...<<<<.....>>>>
...>>>>>>>>>>>>............<<<<<<<<<..<<<.........
>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<
<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>....
...>>>>>>>>>..>>>>><<<..>>>........<...........<<<
<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>
>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<
<<.<<<<.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<
<..>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>.
..>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<..
.<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>
>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))
]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>
>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>
>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>
>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....
<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<<<<<<<.
..<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<
...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<
.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>
>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<
<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>
>>..>..>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7uvx Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome.
• Resolution: 2.35 Å
• Binding residue (original residue number in PDB): M1 R2 H3 R4 N5 S6 G7 K9 R12 H16 K18 N23 L24 T36 P39 K40 K42 R46 E49 T53 R63 R64 R71 R90 N91 G92 G93 R96 K99 R103 G105 D106 A107
• Binding residue (residue number reindexed from 1): M1 R2 H3 R4 N5 S6 G7 K9 R12 H16 K18 N23 L24 T36 P39 K40 K42 R46 E49 T53 R63 R64 R71 R90 N91 G92 G93 R96 K99 R103 G105 D106 A107

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7uvx, PDBe:7uvx, PDBj:7uvx
• PDBsum: 7uvx
• PubMed: 37192172
• UniProt: B7IA13|RL17_ACIB5 Large ribosomal subunit protein bL17 (Gene Name=rplQ)