Structure of PDB 7syp Chain M Binding Site BS01

Receptor Information
>7syp Chain M (length=151) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DIQTERAYQKQPTIFQNKKRVLLGETGKEKLPRYYKNIGLGFKTPKEAIE
GTYIDKKCPFTGNVSIRGRILSGVVTKMKMQRTIVIRRDYLHYIRKYNRF
EKRHKNMSVHLSPCFRDVQIGDIVTVGECRPLSKTVRFNVLKVTKAAGTK
K
Ligand information
>7syp Chain 2 (length=1680) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaau
ucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggau
gcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgc
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucuugcucggcgccggcccgaagcguuuacuuugaaaaaau
uagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaa
uaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaa
gagggacggccgggggcauucguauugcgccgcuagaggugaaauucuug
gaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuuca
uuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucgua
guuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccau
gacccgccgggcagcuuccgggaaaccaaagucuuuggguuccgggggga
guaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccacca
ggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccgg
cccggacacggacaggauugacagauugauagcucuuucucgauuccgug
ggugguggugcauggccguucuuaguugguggagcgauuugucugguuaa
uuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccgg
ucggcguaacuucuuagagggacaaguggcguucagccacccgagauuga
gcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcu
acacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaa
cccguugaaccccauucgugauggggaucggggauugcaauuauucccca
ugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaag
ucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuu
agugaggcccucggaucggccccgccggggugcccuggcggagcgcugag
aagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguu
uccguaggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<......<<....<<<<.........<<.....<<.<<.....
..>>.>>......>>.........<<<<...<<<<<<....>>>>>>...
>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<
...>>>>>>>..>.>>>...>>....>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>
>>>.........<<<...<<<<.....>>>.>>>>......>>.>.....
<<<..<<<..<<<....>>>...>>>...>>>......<<..<.......
....>..>>.........<<<<<((......<<<<.....<<..))>>..
.....>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<.<.<<....<<<<<<.<<..>>>>>>.>>..<<<<<<.<.......
<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>.....
...<.<<.<<<<<<<...............>>>>>>>.>>.>....>>..
..<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>...
...>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>.
..>.>...>>.>....<<<<<<....<...<<<<.<.....>.>>>>...
>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........
>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<..
....<<<......>>>....>>>..)))).]..<...<<<<<<<..<<..
<<<<<.<<<<.<<<<<<......<<........>>..........<<<<<
......<<<<<<........<..<<........>>.>.......>>>>>>
.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<....
..>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>
>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>
>....>>>.>>>.....>>>>>>>>......>>>>>...>>.>>>>.>>>
.>...<<.<<<........<.......<<<.<<<<....>>>>.>>>...
.>.........>>>.>>......<.....<<<<<..........>>>>>.
....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>
>...>>>>>>>..>.......<..<<.<..<<<<.<<....<<<<<<<<.
<<<..<<<<.<<...<<<<<..<<..............>>....>>>>>.
..>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<
<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7syp Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		E7 F17 K20 Y36 N39 I40 L42 K58 K59 N65 S67 I68 R69 R71 K81 M82 T85 Y92 R97 K98 Y99 K104 R105 H106 K107 N108 R132 P133 L134 S135 K136 T137 R139 A149 K152 K153
Binding residue
(residue number reindexed from 1)		E5 F15 K18 Y34 N37 I38 L40 K56 K57 N63 S65 I66 R67 R69 K79 M80 T83 Y90 R95 K96 Y97 K102 R103 H104 K105 N106 R130 P131 L132 S133 K134 T135 R137 A147 K150 K151
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7syp, PDBe:7syp, PDBj:7syp
PDBsum7syp
PubMed35822879
UniProtG1TRM4|RS11_RABIT Small ribosomal subunit protein uS17 (Gene Name=RPS11)

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