Structure of PDB 7s0p Chain M Binding Site BS01

Receptor Information
>7s0p Chain M (length=157) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SCSMPLGMQNKAISDSQITASSHLSNIFATWSPSQARLHLQGRTNAWRPR
VSSAEEWLQVDLQKTVKVTGITTQGVKSLLSSMYVKEFLVSSSQDGRRWT
LFLQDGHTKVFQGNQDSSTPVVNALDPPLFTRYLRIHPTSWAQHIALRLE
VLGCEAA
Ligand information
Ligand IDSEP
InChIInChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
InChIKeyBZQFBWGGLXLEPQ-REOHCLBHSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=P(O)(O)OCC(C(=O)O)N
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)OP(=O)(O)O
CACTVS 3.341N[CH](CO[P](O)(O)=O)C(O)=O
CACTVS 3.341N[C@@H](CO[P](O)(O)=O)C(O)=O
OpenEye OEToolkits 1.5.0C([C@@H](C(=O)O)N)OP(=O)(O)O
FormulaC3 H8 N O6 P
NamePHOSPHOSERINE;
PHOSPHONOSERINE
ChEMBLCHEMBL284377
DrugBankDB04522
ZINCZINC000003869280
PDB chain7s0p Chain M Residue 2401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7s0p Stable binding to phosphatidylserine-containing membranes requires conserved arginine residues in tandem C domains of blood coagulation factor VIII.
Resolution1.3 Å
Binding residue
(original residue number in PDB)		Q2213 N2217 V2248 K2249 S2290 R2320
Binding residue
(residue number reindexed from 1)		Q41 N45 V76 K77 S118 R148
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:7s0p, PDBe:7s0p, PDBj:7s0p
PDBsum7s0p
PubMed36387287
UniProtP12263|FA8_PIG Coagulation factor VIII (Gene Name=F8)

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