Structure of PDB 7qxi Chain M Binding Site BS01

Receptor Information

>7qxi Chain M (length=403) Species: 573 (Klebsiella pneumoniae)

MTPQLQQAIRLLQLSTLELQQELQQALESNPLLEEPVYQGETTQTLQDYL
MWQVELTPFTDTDRAIATSIVDAVDDTGYLTIQIEDIVDSIGDDEIGLEE
VEAVLKRIQRFDPVGVAAKDLRDCLLIQLSQFAKETPWLEEARLIISDHL
DLLANHDFRTLMRVTRLKEEVLKEAVNLIQSLDPRPGQSIQTSEPEYVIP
DVLVRKVSGRWTVELNADSIPRLKINQQYAAMGNSARNDADGQFIRSNLQ
EARWLIKSLESRNDTLLRVSRCIVEQQQAFFEQGEEYMKPMVLADIAQAV
EMHESTISRVTTQKYLHSPRGIFELKYFFSSHVNTEGGGEASSTAIRALV
KKLIAAENPAKPLSDSKLTSMLSEQGIMVARRTVAKYRESLSIPPSNQRK
QLV

Ligand information

>7qxi Chain N (length=36)

agacggctggcacgacttttgcacgatcagccctgg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qxi Mechanisms of DNA opening revealed in AAA+ transcription complex structures.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): M15 T16 P17 V366 L367 R383 K400 S438 R455 R462 P469 N471
• Binding residue (residue number reindexed from 1): M1 T2 P3 V292 L293 R309 K326 S364 R381 R388 P395 N397

Gene Ontology

Molecular Function

• GO:0001216 DNA-binding transcription activator activity
• GO:0003677 DNA binding
• GO:0016491 oxidoreductase activity
• GO:0016779 nucleotidyltransferase activity
• GO:0016987 sigma factor activity

Biological Process

• GO:0006352 DNA-templated transcription initiation
• GO:0006355 regulation of DNA-templated transcription
• GO:0045893 positive regulation of DNA-templated transcription
• GO:2000142 regulation of DNA-templated transcription initiation

Cellular Component

• GO:0000428 DNA-directed RNA polymerase complex

External links

• PDB: RCSB:7qxi, PDBe:7qxi, PDBj:7qxi
• PDBsum: 7qxi
• PubMed: 36542713
• UniProt: A0A0H3H3L1