Structure of PDB 7qwp Chain M Binding Site BS01

Receptor Information

>7qwp Chain M (length=405) Species: 573 (Klebsiella pneumoniae)

MTPQLQQAIRLLQLSTLELQQELQQALESNPLLEEELPVYQGETTQTLQD
YLMWQVELTPFTDTDRAIATSIVDAVDDTGYLTIQIEDIVDSIGDDEIGL
EEVEAVLKRIQRFDPVGVAAKDLRDCLLIQLSQFAKETPWLEEARLIISD
HLDLLANHDFRTLMRVTRLKEEVLKEAVNLIQSLDPRPGQSIQTSEPEYV
IPDVLVRKVSGRWTVELNADSIPRLKINQQYAAMGNSARNDADGQFIRSN
LQEARWLIKSLESRNDTLLRVSRCIVEQQQAFFEQGEEYMKPMVLADIAQ
AVEMHESTISRVTTQKYLHSPRGIFELKYFFSSHVNTEGGGEASSTAIRA
LVKKLIAAENPAKPLSDSKLTSMLSEQGIMVARRTVAKYRESLSIPPSNQ
RKQLV

Ligand information

>7qwp Chain N (length=36)

agacggctggcacgacttttgcacgatcagccctgg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qwp Mechanisms of DNA opening revealed in AAA+ transcription complex structures.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): M15 T16 V366 L367 E378 S379 R383 S438 D439 S440 R455 R462 P468 S470 N471
• Binding residue (residue number reindexed from 1): M1 T2 V294 L295 E306 S307 R311 S366 D367 S368 R383 R390 P396 S398 N399

Gene Ontology

Molecular Function

• GO:0001216 DNA-binding transcription activator activity
• GO:0003677 DNA binding
• GO:0016491 oxidoreductase activity
• GO:0016779 nucleotidyltransferase activity
• GO:0016987 sigma factor activity

Biological Process

• GO:0006352 DNA-templated transcription initiation
• GO:0006355 regulation of DNA-templated transcription
• GO:0045893 positive regulation of DNA-templated transcription
• GO:2000142 regulation of DNA-templated transcription initiation

Cellular Component

• GO:0000428 DNA-directed RNA polymerase complex

External links

• PDB: RCSB:7qwp, PDBe:7qwp, PDBj:7qwp
• PDBsum: 7qwp
• PubMed: 36542713
• UniProt: A0A0H3H3L1