Structure of PDB 7opd Chain M Binding Site BS01

Receptor Information
>7opd Chain M (length=810) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DQDNEIRATDLPERFQLRSIPVKGAEDDELEEEADWIYRNAFATPTISLT
IQKIKEALGFMRNQHFEVPFIAFYRKEYVEPELHINDLWRVWQWDEKWTQ
LRIRKENLTRLFEKMQAYQYEQRALDTTDMERLKDVQSMDELKDVYNHFL
LYYGRDIPLKQASRRDMYTICQSAGLDGLAKKFGLTPEQFGENLRDSYQR
HETEQFPAEPLELAKDYVCSQFPTPEAVLEGARYMVALQIAREPLVRQVL
RQTFQERAKLNITPTKKGRKDVDEAHYAYSFKYLKNKPVKELRDDQFLKI
CLAEDEGLLTTDISIDTYFEEIKQFYYRDEFSHQVQEWNRQRTMAIERAL
QQFLYVQMAKELKNKLLAEAKEYVIKACSRKLYNWLRVAPYRGIRVLGIA
FSSARDHPVFCALVNGEGEVTDFLRLPEEREKKAQDIETLKKFLLNKKPH
VVTVAGENRDAQMLIEDVKRIVHEIGVELVDNELAILYMNSKKSEAEFRD
YPPVLRQAVSLARRIQDPLIEFAQVCSSDEDILCLKFHPLQEHVVKEELL
NALYCEFINRVNEVGVDVNRAIAHPYSQALIQYVCGLGPRKGTHLLKILK
QNNTRLESRTQLVTMCHMGPKVFMNCAGFLKIDEVLDGSRVHPETYEWAR
KMAVDALPAGALEEILENPERLKDLDLDAFAEELERQGYGDKHITLYDIR
AELSCRYKDLRTAYRSPNTEEIFNMLTKETPETFYIGKLIICNVTGIAIG
VKTRLDNGVTGFIPTKFLSDKVVKRPEERVKVGMTVHCRIMKIDIEKFSA
DLTCRTSDLM
Ligand information
>7opd Chain P (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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.....................
Receptor-Ligand Complex Structure
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PDB7opd Structural basis of human transcription-DNA repair coupling.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R790 D791 E825
Binding residue
(residue number reindexed from 1)		R405 D406 E429
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0031491 nucleosome binding
GO:0042393 histone binding
Biological Process
GO:0001825 blastocyst formation
GO:0006139 nucleobase-containing compound metabolic process
GO:0006366 transcription by RNA polymerase II
GO:0006368 transcription elongation by RNA polymerase II
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0010793 regulation of mRNA export from nucleus
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
GO:0034728 nucleosome organization
GO:0045191 regulation of isotype switching
GO:0050684 regulation of mRNA processing
GO:0051028 mRNA transport
GO:0051147 regulation of muscle cell differentiation
GO:0140673 transcription elongation-coupled chromatin remodeling
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0008023 transcription elongation factor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7opd, PDBe:7opd, PDBj:7opd
PDBsum7opd
PubMed34526721
UniProtQ7KZ85|SPT6H_HUMAN Transcription elongation factor SPT6 (Gene Name=SUPT6H)

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