Structure of PDB 7lhd Chain M Binding Site BS01

Receptor Information

>7lhd Chain M (length=419) Species: 39803 (Qubevirus durum)

PKLPRGLRFGADNEILNDFQELWFPDLFIESSDTHPWYTLKGRVLNAHLD
DRLPNVGGRQVRRTPHRVTVPIASSGLRPVTTVQYDPAALSFLLNARVDW
DFGNGDSANLVINDFLFRTFAPKEFDFSNSLVPRYTQAFSAFNAKYGTMI
GEGLETIKYLGLLLRRLREGYRAVKRGDLRALRRVIQSYHNGKWKPATAG
NLWLEFRYGLMPLFYDIRDVMLDWQNRHDKIQRLLRFSVGHGEDYVVEFD
NLYPAVAYFKLKGEITLERRHRHGISYANREGYAVFDNGSLRPVSDWKEL
ATAFINPHEVAWELTPYSFVVDWFLNVGDILAQQGQLYHNIDIVDGFDRR
DIRLKSFTIKGERNGRPVNVSASLSAVDLFYSRLHTSNLPFATLDLDTTF
SSFKHVLDSIFLLTQRVKR

Ligand information

>7lhd Chain A (length=4217)

ggggacccccuuuagggggucaccucacacagcaguacuucacugaguau
aagaggacauaugccuaaauuaccgcguggucugcguuucggagccgaua
augaaauucuuaaugauuuucaggagcucugguuuccagaccucuuuauc
gaaucuuccgacacgcauccgugguacacacugaagggucguguguugaa
cgcccaccuugaugaucgucuaccuaauguaggcggucgccagguaaggc
gcacuccacaucgcgucaccguuccgauugccucuucaggccuucguccg
guaacaaccguucaguaugaucccgcagcacuaucguucuuauugaacgc
ucguguugacugggauuucgguaauggcgauagugcgaaccuugucauua
augacuuucuguuucgcaccuuugcaccuaaggaguuugauuuuucgaac
uccuuaguuccucguuauacucaggccuucuccgcguuuaaugccaagua
uggcacuaugaucggcgaagggcucgagacuauaaaauaucucgggcuuu
uacugcgcagacugcgugaggguuaccgcgcuguuaagcguggcgauuua
cgugcucuucguaggguuauccaguccuaccauaaugguaaguggaaacc
ggcuacugcugguaaucucuggcuugaauuucguuauggccuuaugccuc
ucuuuuaugacaucagagaugucauguuagacuggcagaaccgucaugau
aagauucaacgccuccuucgguuuucuguuggucacggcgaggauuacgu
ugucgaauucgacaaucuguacccugccguugcuuacuuuaaacugaaag
gggagauuacacucgaacgccgucaucgucauggcauaucuuacgcuaac
cgcgaaggauaugcuguuuucgacaacgguucccuucggccuguguccga
uuggaaggagcuugccacugcauucaucaauccgcaugaaguugcuuggg
aguuaacucccuacagcuucguuguugauugguucuugaauguuggugac
auacuugcucaacaaggucagcuauaucauaauaucgauauuguagacgg
cuuugacagacgugacauccggcucaaaucuuucaccauaaaaggugaac
gaaaugggcggccuguuaacguuucugcuagccugucugcugucgauuua
uuuuacagccgacuccauacgagcaaucuuccguucgcuacacuagaucu
ugauaccaccuuuaguucguuuaaacacguucuugauaguaucuuuuuau
uaacccaacgcguaaagcguugaaacuuugggucaauuugaucauggcaa
aauuagagacuguuacuuuagguaacaucgggaaagauggaaaacaaacu
cugguccucaauccgcgugggguaaaucccacuaacggcguugccucgcu
uucacaagcgggugcaguuccugcgcuggagaagcguguuaccguuucgg
uaucucagccuucucgcaaucguaagaacuacaagguccagguuaagauc
cagaacccgaccgcuugcacugcaaacgguucuugugacccauccguuac
ucgccaggcauaugcugacgugaccuuuucguucacgcaguauaguaccg
augaggaacgagcuuuuguucguacagagcuugcugcucugcucgcuagu
ccucugcugaucgaugcuauugaucagcugaacccagcguauugaacacu
gcucauugccggugguggcucagggucaaaacccgauccgguuauuccgg
auccaccgauugauccgccgccagggacagguaaguauaccugucccuuc
gcaauuuggucccuagaggagguuuacgagccuccuacuaagaaccgacc
guggccuaucuauaaugcuguugaacuccagccucgcgaauuugauguug
cccucaaagaucuuuugggcaauacaaaguggcgugauugggauucucgg
cuuaguuauaccacguuccgcgguugccguggcaaugguuauauugaccu
ugaugcgacuuaucuugcuacugaucaggcuaugcgugaucagaaguaug
auauucgcgagggcaagaaaccuggugcuuucgguaacauugagcgauuc
auuuaucuuaagucgauaaaugcuuauugcucucuuagcgauauugcggc
cuaucacgccgauggcgugauaguuggcuuuuggcgcgauccauccagcg
guggugccauaccguuugacuucacuaaguuugauaagacuaaauguccu
auucaagccgugauagucguuccucgugcuuaguaacuaaggaugaaaug
caugucuaagacagcaucuucgcguaacucucucagcgcacaauugcgcc
gagccgcgaacacaagaauugagguugaagguaaccucgcacuuuccauu
gccaacgauuuacuguuggccuauggucagucgccauuuaacucugaggc
ugaguguauuucauucagcccgagauucgacgggaccccggaugacuuua
ggauaaauuaucuuaaagccgagaucaugucgaaguaugacgacuucagc
cuagguauugauaccgaagcuguugccugggagaaguuccuggcagcaga
ggcugaaugugcuuuaacgaacgcucgucucuauaggccugacuacagug
aggauuucaauuucucacugggcgagucauguauacacauggcucguaga
aaaauagccaagcuaauaggagauguuccguccguugaggguauguugcg
ucacugccgauuuucuggcggugcuacaacaacgaauaaccguucguacg
gucauccguccuucaaguuugcgcuuccgcaagcguguacgccucgggcu
uugaaguauguuuuagcucucagagcuucuacacauuucgauaucagaau
uucugauauuagcccuuuuaauaaagcaguuacuguaccuaagaacagua
agacagaucguuguauugcuaucgaaccugguuggaauauguuuuuccaa
cuggguaucgguggcauucuacgcgaucgguugcguugcugggguaucga
ucugaaugaucagacgauaaaucagcgccgcgcucacgaaggcuccguua
cuaauaacuuagcaacgguugaucucucagcggcaagcgauucuauaucu
cuugcccucugugagcucuuauugcccccaggcugguuugagguucuuau
ggaccucagaucaccuaaggggcgauugccugacgguaguguuguuaccu
acgagaagauuucuucuauggguaacgguuacacauucgagcucgagucg
cuuauuuuugcuucucucgcucguuccguuugugagauacuggacuuaga
cucgucugaggucacuguuuacggagacgauauuauuuuaccguccugug
cagucccugcccuccgggaaguuuuuaaguauguugguuuuacgaccaau
acuaaaaagacuuuuuccgaggggccguucagagagucgugcggcaagca
cuacuauucuggcguagauguuacucccuuuuacauacgucaccguauag
ugaguccugccgauuuaauacugguuuugaauaaccuauaucggugggcc
acaauugacggcguaugggauccuagggcccauucuguguaccucaagua
ucguaaguugcugccuaaacagcugcaacguaauacuauaccugaugguu
acggugauggugcccucgucggaucgguccuaaucaauccuuucgcgaaa
aaccgcggguggauccgguacguaccggugauuacggaccauacaaggga
ccgagagcgcgcugaguuggggucguaucucuacgaccucuucucgcguu
gucucucggaaaguaacgauggguugccucuuagggguccaucggguugc
gauucugcggaucuauuugccaucgaucagcuuaucuguaggaguaaucc
uacgaagauaagcaggucuaccggcaaauucgauauacaguauaucgcgu
gcaguagccguguucuggcacccuacggggucuuccagggcacgaagguu
gcgucucuacacgaggcguaaccugggagggcgccaauauggcgccuaau
ugugaauaaauuaucacaauuacucuuacgagugagagggggaucugcuu
ugcccucucuccuccca

<<<<<<<<<<<..>>>>>>>>.>>>....<<<<<<<<.....<<<<<<<<
<<<<<<<<<<.<<<<.....<<<<<<<.<<..<<<<<.<<<<<..<..<<
<<<<<.............>>>>.<<<.<<<.......>>>.>>>.>>>..
>.....>>>>>.>>>>>>>>>>>>>>...<<<<<<.<<...<.<<<.<..
<<<<.<<<.<<..<<<<<<<<<<.....>>>>>>>>>>..>>>>>..>>>
>....>.>>>..>..<.<<<.....<<..<<<......>>>..>>....>
>>.>...>>.>>>>>>...<<<<<.<<<<<<...<<<<<.....>>>>>.
..>>>>>>...>>>>>...>>>>>>>..<<..<<<<<<<<...<<<<...
.>>>>.....>>>.>>>>>..>>..<<.<<<<<<<<<<<<....>>>>>>
>>>>>>>>>>>>>.>>>>>>>>>>.<<<<<.<<<..<.<<.<<<<<....
>>>>>.>>.>..>>>.>>>>><<<<<<<<..........>>>>>>>>...
..<<<<<.<<<..<<<<<.......<<<<<<<....>>>>>>>.....>>
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>.>>>>>>>>....<....<<<<..<<<..<<<<<<<<<<<<.<<<....
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......<<<<......<<<.<<<.<<..<<<<.<<<<<<....<<<<<<<
<<....<<<<<<<<<<<.<<<.<<<<..<..<<<<<<......>>>>>>.
.>..>>>>>>>..>>>>.>>>..>>>>..>>>>.>>>>>..>>>>>>>>>
>..>>.>>>.>>>.......>>>>...>>......>..............
...<<<.<.....<<..<<<......>>>..>>...>.>>>.........
.....<<<<<<.....>>>>>>......<<<<<<<<<<<<.......>>.
>>>>..<<<.<<<<<<<...>>>>>>><<<<<.....<<<<.....<<.<
<<<<..<<<<<.<<<.<<<<<<....>>>>>>...>>>..>>>.<<<<<<
<....>>>>>>><<.<<<<<.<<<..<<.<<<<<...<..<<<<...>>>
>....>...>>>>>..>>...>>>.>>>>>.>>>>..>>>>>>>....>>
>>...>>>>><<<.<<<.....>>>.>>>.>>>...>>>>>>...<<<.<
<<<...<<.<<<<<<<<.<<<<<<......>>.>>>>>>>>>>>.>.>>.
.>>>>.>>><<<<...<<<<<<<.<<<<<<.....>>>>>>..<<<<...
..<<.<<<<<<<<<<...>>>>>>>>>>.>>....>>>>.>>.>>>>>..
>>>>......<<<<<<<<.<<<<<<<....>>>>.<<<<<<.....>>>>
>>........>>>.>>>>>>>><<<<<<<<<<<....>>>>>>>>>>>.<
<<<<<.<<<<.<.<<<<<<<<<<..((((>>>>>>>.>>>.>.>>>>..<
<<<<..<<....<<<.<<<...<<<.<<<<<.<.<<<.<.<<<<.<<<<<
<<<..<<<....>>>.>>>>>>>>>>>>.>.>>>.>.>>>>>.>>>..>>
>>>>..>>..>>>>>...<<<.<<<<<<<.<<<<..<<<.........<<
<..<<<<...<<<<.<<<<.<<<<<<<.<<...>>.>>>>>>>.>>>>.>
>>>..>>>>>>>.......>>>...>>>>..>>>>>>>...<<<<<<..<
<<<<<<<.......>>>>>>>>....>>>>>>.....>>>..>>>>>>..
<<<<<<<<<<...>>>>>>>>>>.<<<....<<<<<<...<<.......>
>..>>>>>>..>>>..<<<<<<<<<...<<<<<.<<.<<<.....>>>.>
>..>>>>>.>>>>.>>>>>....<<<..<<<<<...>>>>>..>>>.<<<
<.<<<<...>>>>>>>>.<<<<<<.....<<<...<<<<<....>>>>>.
>>>.>>>>>>..........<<<<<..<<<<<<.<<<.<<<<...<<<<.
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((..>>>.>>.>>>....>>>>>>>...>>>.>>>>.>>>.>><<<<<..
.<<<<<<<...)))).>>>>>>>...>>>>><<<.<<.<<<<.)))).>>
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<<<<<....>>>>>>>>>>..>>>>>>.>>>.<<<<<..<<<<.<<<<<.
<<<<....>>>>.>>>>>..<<.<<..<<<.<<<<<<.<<<.....>>>.
>>>>>>..>>>..>>.>>..<<<<<<<<.<<<.<<<<<<<<<<.<<....
>>.>>>>>>>>>>>>>..>>>>>>>>.>>>>.<<<...<<<.<<<<<<<<
..<...........>....>>>>>>>>....>>>...<<<<...<<<..<
<........>>..>>>...>>>>...>>>..>>>>>..>>>>..>>>><<
<<..<<<<.<<..<<<<..<<<<..<<<<.<<......>>.>>>>.>>>>
>>>>.>.><<<<<.<<<<<<<<<<<...<...<<<<<<......>>>>>>
..>...>>>>>>>..>>>>.>>>>><<<.<<<<<..<.<<.........>
>.>...>>>>>>>>>>>>..<<...<<<<......<<<<<<..<<.<<.<
<<.<<<<.<<<<<<.<<.....<<<<......>>>>>>.>>>>>>>>>>>
>>.>>>>..>>>>>>...<<<<<.<<<<<<<<<.<<<<<.<<<<<<.<<<
<.<<..<<<<<.<<.......>>.>>>>>.....>>.>>>>.>>>.>>>>
>>>>..>>>>.>>>>>....>>>>><<<<<<<<<<..<<<.<<<<.....
.....>>>>.>>>.<<<<<....>>>>>.>>>>>.>>>>>.....>>>>.
<<<<<<<.<<<.<<<<..<<<<<<<<<....>>>>>>>>>..>>>>>>>.
..>>>>>>>.....>><<<<<<....<<<.....>>>.>>>>>>>>>><<
<<<.<<<...<<<.<<<<<<<...<<<<.<<<<<<<.<<.<<......>>
.>>...>>>>>>>.>>>>....>>>>>>>..>>>...>>>...>>>>>>>
>>>>>>>.<<<<<<<<<<.<<<<....>>>>...>>>>>>>>>>..<<<<
<<<<<<<.....>>>>>>>>>>><<<<<..<<<<<<...>>>>>>..<<<
<<<<<........>>>>>>>><<<<....>>>><<<<<<<<.........
...>>>>>>>>.>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7lhd Structural Assembly of Q beta Virion and Its Diverse Forms of Virus-like Particles.
• Resolution: 4.6 Å
• Binding residue (original residue number in PDB): I15 H66 R67 V68 T69 R78 P79 V80 T81 Y85 K158 R165 R172 R176 R180 R184 G192 K193 K230 R236 V294 F347 R349 R353 Y381 R383 R416
• Binding residue (residue number reindexed from 1): I15 H66 R67 V68 T69 R78 P79 V80 T81 Y85 K158 R165 R172 R176 R180 R184 G192 K193 K230 R236 V294 F347 R349 R353 Y381 R383 R416

Gene Ontology

Biological Process

• GO:0031640 killing of cells of another organism
• GO:0039635 suppression by virus of host peptidoglycan biosynthetic process
• GO:0039636 suppression by virus of host cell wall biogenesis
• GO:0039640 viral release via suppression of host peptidoglycan biosynthetic process
• GO:0039666 virion attachment to host cell pilus
• GO:0044659 viral release from host cell by cytolysis
• GO:0046718 symbiont entry into host cell
• GO:0098671 adhesion receptor-mediated virion attachment to host cell

Cellular Component

• GO:0044423 virion component

External links

• PDB: RCSB:7lhd, PDBe:7lhd, PDBj:7lhd
• PDBsum: 7lhd
• PubMed: 35215818
• UniProt: Q8LTE2|MATA2_BPQBE Maturation protein A2