Structure of PDB 7kzs Chain M Binding Site BS01

Receptor Information
>7kzs Chain M (length=370) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAVTEASLLRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVLPEDLQLKN
ARLLCSWQLRTILSGYHRIVQQRMQHSPDLMSFMMELKMLLEVALKNRQE
LYALPPPPQFYSSLIEEIGTLGWDKLVYADTCFSTIKLKAEDASGREHLI
TLKLKAKYPAESPDYFVDFPVPFCASWTPQSSLISIYSQFLAAIESLKAF
WDVMDEIDEKTWVLEPEKPPRSATARRIALGNNVSINIEVDPRHPTMLPE
CFFLGADHVVKPLGIKLSRNIHLWDPENSVLQNLKDVLEIDFPARAILEK
SDFTMDCGICYAYQLDGTIPDQVCDNSQCGQPFHQICLYEWLRGLLTSRQ
SFNIIFGECPYCSKPITLKM
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7kzs Chain M Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7kzs Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		C307 H334 C337
Binding residue
(residue number reindexed from 1)		C307 H334 C337
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0006281 DNA repair
GO:0006513 protein monoubiquitination
GO:0006974 DNA damage response
GO:0007276 gamete generation
GO:0016567 protein ubiquitination
GO:0036297 interstrand cross-link repair
GO:0042127 regulation of cell population proliferation
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016604 nuclear body
GO:0043231 intracellular membrane-bounded organelle
GO:0043240 Fanconi anaemia nuclear complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7kzs, PDBe:7kzs, PDBj:7kzs
PDBsum7kzs
PubMed33686268
UniProtQ9NW38|FANCL_HUMAN E3 ubiquitin-protein ligase FANCL (Gene Name=FANCL)

[Back to BioLiP]