Structure of PDB 7eu1 Chain M Binding Site BS01

Receptor Information
>7eu1 Chain M (length=1055) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TNRSTVKISNVPQTIVADELLRFLELHLGEDTVFALEIPTTRDNWKPRDF
ARVQFTTLEVKSRAQLLSSQSKLLFKTHNLRLSEAYDDIIPRPVDPRKRL
DDIVLTVGFPESDEKRFCALEKWDGVRCWILTEKRRVEFWVWESGDCYKI
EVRFEDIIETLSCCVNGDASEIDAFLLKLKYGPKVFKRVTRYRFCKEDFD
FMWIRTTDFSGSKSIGTSTCFCLEVHNGSTMLDIFSGLPYYREDTLSLTY
VDGKTFASAAQIVPLLNAAILGLEFPYEILFQLNALVHAQKISLFAASDM
ELIKILRGMSLETALVILKKLHQQSSICYDPVFFVKTQMQSVVKKASAYK
RLTEQNIMSCQRAYVTPSKIYLLGPELETANYVVKNFAEHVSDFMRVTFV
EEDWSKLPANALSVNSKEGYFVKPSRTNIYNRVLSILGEGITVGPKRFEF
LAFSASQLRGNSVWMFASNEKVKAEDIREWMGCFRKIRSISKCAARMGQL
FSASRQTLIVRAQDVEQIPDIEVTTDGADYCFSDGIGKISLAFAKQVAQK
CGLSHVPSAFQIRYGGYKGVIAVDRSSFRKLSLRDSMLKFDSNNRMLNVT
RWTESMPCFLNREIICLLSTLGIEDAMFEAMQAVHLSMLGNMLEDRDAAL
NVLQKLSGENSKNLLVKMLLQGYAPSSEPYLSMMLRVHHESQLSELKSRC
RILVPKGRILIGCMDEMGILEYGQVYVRVTIGKVVVTKNPCLHPGDIRVL
DAIYEVHFEEKGYLDCIIFPQKGERPHPNECSGGDLDGDQFFVSWDEKII
PSEMDPPMDYAGSRPRLMDHDVTLEEIHKFFVDYMISDTLGVISTAHLVH
ADRDPEKARSQKCLELANLHSRAVDFAKTGAPAEMPYALKPREFPDFLER
FEKPTYISESVFGKLYRAVKSSLAQRGFESFIETAKAHRDMYGEKLTSLM
IYYGAANEEEILTGILKTKEMYLARDNRRYGDMKDRITLSVKDLHKEAMG
WFEKSCEDEQQKKKLASAWYYVTYNPNHRDEKLTFLSFPWIVGDVLLDIK
AENAQ
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7eu1 Chain M Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7eu1 Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA.
Resolution3.86 Å
Binding residue
(original residue number in PDB)		D830 D832 D834
Binding residue
(residue number reindexed from 1)		D785 D787 D789
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005515 protein binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0009751 response to salicylic acid
GO:0010468 regulation of gene expression
GO:0010495 siRNA-mediated long-distance post-transcriptional gene silencing
GO:0030422 siRNA processing
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0050832 defense response to fungus
GO:0140745 siRNA transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7eu1, PDBe:7eu1, PDBj:7eu1
PDBsum7eu1
PubMed34941388
UniProtO82504|RDR2_ARATH RNA-dependent RNA polymerase 2 (Gene Name=RDR2)

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