Structure of PDB 7eu0 Chain M Binding Site BS01

Receptor Information
>7eu0 Chain M (length=1052) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TNRSTVKISNVPQTIVADELLRFLELHLGEDTVFALEIPTTRDNWKPRDF
ARVQFTTLEVKSRAQLLSSQSKLLFKTHNLRLSEAYDDIIPRPVDPRKRL
DDIVLTVGFPESDEKRFCALEKWDGVRCWILTEKRRVEFWVWESGDCYKI
EVRFEDIIETLSCCVNGDASEIDAFLLKLKYGPKVFKRVTDRYRFCKEDF
DFMWIRTTDFSGSKSIGTSTCFCLEVHNGSTMLDIFSGLPYYREDTLSLT
YVDGKTFASAAQIVPLLNAAILGLEFPYEILFQLNALVHAQKISLFAASD
MELIKILRGMSLETALVILKKLHQQSSICYDPVFFVKTQMASAYKRLTEQ
NIMSCQRAYVTPSKIYLLGPELETANYVVKNFAEHVSDFMRVTFVEEDWS
KLPANALSVNSKEGYFVKPSRTNIYNRVLSILGEGITVGPKRFEFLAFSA
SQLRGNSVWMFASNEKVKAEDIREWMGCFRKIRSISKCAARMGQLFSASR
QTLIVRAQDVEQIPDIEVTTDGADYCFSDGIGKISLAFAKQVAQKCGLSH
VPSAFQIRYGGYKGVIAVDRSSFRKLSLRDSMLKFDSNNRMLNVTRWTES
MPCFLNREIICLLSTLGIEDAMFEAMQAVHLSMLGNMLEDRDAALNVLQK
LSGENSKNLLVKMLLQGYAPSSEPYLSMMLRVHHESQLSELKSRCRILVP
KGRILIGCMDEMGILEYGQVYVRVTLTKAELKSRDQSYFRKIDEETSVVI
GKVVVTKNPCLHPGDIRVLDAIYEVHFEEKGYLDCIIFPQKGERPHPNEC
SGGDLDGDQFFVSWDEKIIPSEMDPPMDYAGSRPRLMDHDVTLEEIHKFF
VDYMISDTLGVISTAHLVHADRDPEKARSQKCLELANLHSRAVDFAKTGA
PAEMPYALKPREFPDFLERFEKPTYISESVFGKLYRAVKSSLATAKAHRD
MYGEKLTSLMIYYGAANEEEILTGILKTKEMYLARDNRRYGDMKDRITLS
VKDLHKEAMGWFEKSCEDEQQKKKLASAWYYVTYNPNHRDEKLTFLSFPW
IV
Ligand information
>7eu0 Chain O (length=32) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgagagguacuuuucuuuucuuucuucuucgg
................................
Receptor-Ligand Complex Structure
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PDB7eu0 Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA.
Resolution3.16 Å
Binding residue
(original residue number in PDB)		Y92 N431 E625 F630 N632 R722 N784 L885 G886 S889 Y932 R937 E944 R1039
Binding residue
(residue number reindexed from 1)		Y86 N405 E599 F604 N606 R696 N758 L859 G860 S863 Y906 R911 E918 R985
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005515 protein binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0009751 response to salicylic acid
GO:0010468 regulation of gene expression
GO:0010495 siRNA-mediated long-distance post-transcriptional gene silencing
GO:0030422 siRNA processing
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0050832 defense response to fungus
GO:0140745 siRNA transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7eu0, PDBe:7eu0, PDBj:7eu0
PDBsum7eu0
PubMed34941388
UniProtO82504|RDR2_ARATH RNA-dependent RNA polymerase 2 (Gene Name=RDR2)

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