Structure of PDB 7cow Chain M Binding Site BS01

Receptor Information

>7cow Chain M (length=108) Species: 9606 (Homo sapiens)

AKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAE
ILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNI
QAVLLPKK

Ligand information

>7cow Chain I (length=353)

cgctgcgaaaaaaaaaacgcatcccggtgccgaggccgctcaattggtcg
tagacagctctagcaccgcttaaacgcacgtacgcgctgtctaccgcgtt
ttaaccgccactagaagcgcttactagtctccaggcacgtgtgagaccgg
cacatgaaaaaaaaaatgcatgctcgagtatgaaaaaaaaaatcgcatcc
cggtgccgaggccgctcaattggtcgtagacagctctagcaccgcttaaa
cgcacgtacgcgctgtctaccgcgttttaaccgccactagaagcgcttac
tagtctccaggcacgtgtgagaccggcacatgaaaaaaaaaacgcagcgg
tac

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7cow Engineering nucleosomes for generating diverse chromatin assemblies.
• Resolution: 2.86 Å
• Binding residue (original residue number in PDB): A14 K15 R17 R20 R29 R32 R42 R77
• Binding residue (residue number reindexed from 1): A3 K4 R6 R9 R18 R21 R31 R66

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0030527 structural constituent of chromatin
• GO:0031492 nucleosomal DNA binding
• GO:0046982 protein heterodimerization activity

Biological Process

• GO:0006325 chromatin organization
• GO:0008285 negative regulation of cell population proliferation
• GO:0031507 heterochromatin formation
• GO:0061644 protein localization to CENP-A containing chromatin

Cellular Component

• GO:0000786 nucleosome
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0043505 CENP-A containing nucleosome
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:7cow, PDBe:7cow, PDBj:7cow
• PDBsum: 7cow
• PubMed: 33590100
• UniProt: P04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)