Structure of PDB 7b7u Chain M Binding Site BS01

Receptor Information
>7b7u Chain M (length=108) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VRKKIEFERKALHIVEQLLEENITEEFLMECGRFITPAHYSDVVDERSIV
KLCGYPLCQKKLGIVPKQKYKISTKTNKVYDITERKSFCSNFCYQASKFF
EAQIPKTP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7b7u Chain M Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7b7u Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2.
Resolution2.8 Å
Binding residue
(original residue number in PDB)
C100 C140
Binding residue
(residue number reindexed from 1)
C53 C93
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity
GO:0017018 myosin phosphatase activity
GO:0043175 RNA polymerase core enzyme binding
GO:0046872 metal ion binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0009301 snRNA transcription
GO:0036499 PERK-mediated unfolded protein response
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0097550 transcription preinitiation complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:7b7u, PDBe:7b7u, PDBj:7b7u
PDBsum7b7u
PubMed34021257
UniProtQ8IXW5|RPAP2_HUMAN Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (Gene Name=RPAP2)

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