Structure of PDB 7a23 Chain M Binding Site BS01

Receptor Information

>7a23 Chain M (length=482) Species: 3712 (Brassica oleracea)

LSGLILCPVLGSIILLFIPNSRIRLIRLIGLCASLITFLYSLVLWIQFDS
STAKFQFVESLRWLPYENINFYLGIDGISLFFVILTTFLIPICILVGWSG
MRSYGKEYIIAFLICEFLMIAVFCMLDLLLFYVFPESVLIPMFIIIGVWG
SRQRKIKAAYQFFLYTLLGSLFMLLAILLILFQTGTTDLQILLTTEFSER
RQIFLWIAFFASFAVKVPMVPVHIWLPEAHVEAPTAGSVILAGILLKFGT
YGFLRFSIPMFPEATLCFTPFIYTLSAIAIIYTSLTTLRQIDLKKIIAYS
SVAHMNLVTIGMFSPNIQGIGGSILLMLSHGLVSSALFLCVGVLYDRHKT
RLVRYYGGLVSTMPNFSTIFFSFTLANMSLPGTSSFIGEFLILVGAFQRN
SLVATLAALGMILGAAYSLWLYNRVVSGNLKPDFLHKFSDLNGREVFIFI
PFLVGLVWMGVYPKVFLDCMHTSVSNLVQHGK

Ligand information

>7a23 Chain l (length=23) Species: 3712 (Brassica oleracea)

GIFGIALPIIVYKGIVKDFHMQD

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7a23 Specific features and assembly of the plant mitochondrial complex I revealed by cryo-EM.
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): T285 L413
• Binding residue (residue number reindexed from 1): T274 L402

Enzymatic activity

• Enzyme Commision number: 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).

Gene Ontology

Molecular Function

• GO:0003954 NADH dehydrogenase activity
• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0048039 ubiquinone binding

Biological Process

• GO:0009060 aerobic respiration
• GO:0015990 electron transport coupled proton transport
• GO:0042773 ATP synthesis coupled electron transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0009536 plastid
• GO:0045271 respiratory chain complex I

External links

• PDB: RCSB:7a23, PDBe:7a23, PDBj:7a23
• PDBsum: 7a23
• PubMed: 33060577
• UniProt: P93313|NU4M_ARATH NADH-ubiquinone oxidoreductase chain 4 (Gene Name=ND4)