Structure of PDB 6zku Chain M Binding Site BS01

Receptor Information

>6zku Chain M (length=459) Species: 9940 (Ovis aries)

MLKYIIPTMMLMPLTWLSKNSMIWINTTLHSLLISLTSLLLLNQFGDNSL
NFSLTFFSDSLSTPLLILTMWLLPLMLMASQHHLSKENLARKKLFISMLI
LLQLFLIMTFTATELIFFYIMFEATLVPTLIIITRWGNQTERLNAGLYFL
FYTLAGSLPLLVALIYIQNTMGSLNFLILQYWVQPMPNSWSNTFMWLACM
MAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAILLKLGGYGMMRITLLL
NPITDFMAYPFIMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVA
ILIQTPWSYMGATALMIAHGLTSSMLFCLANSNYERVHSRTMILARGLQT
LLPLMAAWWLLASLTNLALPPSINLIGELFVVMSTFSWSNITIILMGLNM
VITALYSLYMLITTQRGKHTHHINNILPSFTRENALMSLHMLPLLLLSLN
PKIILGPLY

Ligand information

>6zku Chain V (length=19) Species: 9940 (Ovis aries)

ALVKMGQLEGWKVFAEPKV

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zku The coupling mechanism of mammalian respiratory complex I.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): W190 S191 F194
• Binding residue (residue number reindexed from 1): W190 S191 F194

Enzymatic activity

• Enzyme Commision number: 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).

Gene Ontology

Molecular Function

• GO:0003954 NADH dehydrogenase activity
• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0048039 ubiquinone binding

Biological Process

• GO:0006120 mitochondrial electron transport, NADH to ubiquinone
• GO:0009060 aerobic respiration
• GO:0015990 electron transport coupled proton transport
• GO:0032981 mitochondrial respiratory chain complex I assembly
• GO:0042773 ATP synthesis coupled electron transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0045271 respiratory chain complex I

External links

• PDB: RCSB:6zku, PDBe:6zku, PDBj:6zku
• PDBsum: 6zku
• PubMed: 32972993
• UniProt: O78755|NU4M_SHEEP NADH-ubiquinone oxidoreductase chain 4 (Gene Name=MT-ND4)