Structure of PDB 6wru Chain M Binding Site BS01

Receptor Information

>6wru Chain M (length=56) Species: 1280 (Staphylococcus aureus)

AKLQITLTRSVIGRPETQRKTVEALGLKKTNSSVVVEDNPAIRGQINKVK
HLVTVE

Ligand information

>6wru Chain 1 (length=2665)

uaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaa
ggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugau
ccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucg
auaugugaauacauagcauaucagaaggcacacccggagaacugaaacau
cuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcg
agcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguuguag
gacacucuaguuacaaaggacgacauuagacgaaucaucuggaaagauga
aucaaagaagguaauaauccuguagucgaaaauguugucucucuugagug
gauccugaguacgacggagcacgugaaauuccgucggaaucugggaggac
caucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccg
ugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaa
accgugugcuuacaaguagucagagcccguuaaugggugauggcgugccu
uuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaa
auguggagccguagcgaaagcgagucugaauagggcguuuaguauuuggu
cguagacccgaaaccaggugaucuacccuuggucagguugaaguucaggu
aacacugaauggaggaccgaaccgacuuacguugaaaagugagcggauga
acugaggguagcggagaaauuccaaucgaaccuggagauagcugguucuc
uccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagag
cacuguuuggacucagacaaacuccgaaugccaauuaauuuaacuuggga
gucagaacaugggugauaagguccguguucgaaagggaaacagcccagac
caccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguu
gccgugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagc
uguggauuguccuuuggacaaugguaggagagcguucuaagggcguugaa
gcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugug
aguagcgaaagacgggugagaaucccguccaccgauugacuaagguuucc
agaggaaggcucguccgcucuggguuagucggguccuaagcugaggccga
caggcguaggcgauggauaacagguugauauuccuguaccaccuauaucg
auggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgucu
aagcaguaaggauccgguacgcugagcugugauggggagaagacauugug
ucuucgagucguugauuucacacugccgagaaaagccucuagggugcccg
uaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgag
cgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaa
ggggugcucuuuagggucccagaagagccgcagugaauaggcccaagcga
cuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauagg
ggcugacgccugcccagugcuggaagguuaagaggagugguuagcuucug
cgaagcuacgaaucgaagccccaguaaacggcggccguaacuauaacggu
ccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaagg
cguaacgauuugggcacugucucaacgagagacucggugaaaucauagua
ccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagc
uuuacuguagccugauauugaaaugcuuucuaacccgcaccacuuaucgu
ggugggagacagugucaggcgggcaguuugacuggggcggucgccuccua
aaagguaacggaggcgcucaaagguucccucagaaauucauagaguguaa
aggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaa
gacggacuuagugauccggugguuccgcauggaagggccaucgcucaacg
gauaaaagcuaccccggggauaacaggcuuaucucccccaagaguucaca
ucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcu
guagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgag
cuggguucagaacgucgugagacaguucggucccuauccgucgugggcgu
aggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacau
accucugguguaccaguugucgugccaacggcauagcuggguagcuaugu
guggacgggauaagugcugaaagcaucuaagcaugaagccccccucaaga
ugagauuucccaacuucgguuauaagaucccucaaagaugaugagguuaa
uagguucgagguggaagcauggugacauguggagcugacgaauacuaauc
gaucgaagacuuaau

<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......
<<<<<<.[...((.>>>.....<<<<<<<..<<<))...].>>>.....>
>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<
<<<<<<.........>>>>>>>.>>.>>....<<<<<......<......
>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<<<........>>>>>>......<<
<<<<<<<...........<.<<<<<<<.<<<...<<<<<......>>>>>
((......<<<.....))>>>...>>>...>>>>>>>..>.....>>>>>
..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<
<<<>>>>>..)))......]].>>>>>>>.]]...............<<.
...>>....]].........<<<<....>>>>.............}....
>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<
........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<....
.>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>
>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<..
....>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....
>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<
<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<
...<<<<<<<..>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.
>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<
<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<
<...>>>>.>>>>.>>...........))).....>>>>>>.>>>...>>
>>>>><<<<<<.....>>>>>>....>>>>>><.<<<<<<<.<<......
<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><..
....<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<
<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<..
..>>>...>>>...>>...<<<<<........>>>>>))<<<<.......
..<<<<....<<<<...<<...<....<.<<<.....{...>>>.>.<..
..<<<<...<<..........>>...>>>>.....>.....<<.......
..>>........>....>>...>>>>.........>>>.>..>>>>>>>>
..>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<
....<<<<<<<<.<<.........<.....<<<<<....<....>.....
>>>>><<<<<<<.<<<.>>>.>>>>>>>............<<<<<<<<<.
.<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>
>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<....>
>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>
>........<...........<<<<<.......>>>>>.....>....>>
>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<
<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<
<..<<<<<.<<<<<<<<<.<<<<...>>>>....<<.<<<<<<.....>>
>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<..
.........>>>>>>..<<...<<<<<<<...<<<.>>>.....<<.[.(
((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....
>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.......
......>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......
>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<
......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>
>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>...
.<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<
<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>
>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>....
...>>>>>>>.<<<....>>>....<<<<<<<<<.......>>>>>....
<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...
>>>>....>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6wru Characterization of the Core Ribosomal Binding Region for the Oxazolidone Family of Antibiotics Using Cryo-EM.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): S11 I13 G14 R20 K21 A25 K30 T31 A42 G45 Q46 K49
• Binding residue (residue number reindexed from 1): S10 I12 G13 R19 K20 A24 K29 T30 A41 G44 Q45 K48

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6wru, PDBe:6wru, PDBj:6wru
• PDBsum: 6wru
• PubMed: 32566908
• UniProt: P0A0G2|RL30_STAA8 Large ribosomal subunit protein uL30 (Gene Name=rpmD)