Structure of PDB 6u8q Chain M Binding Site BS01

Receptor Information
>6u8q Chain M (length=194) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLA
GRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGVIESMNKELKKIIGQ
VRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQNFRVY
YRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRD
Ligand information
Receptor-Ligand Complex Structure
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PDB6u8q A Peptide Derived from Lens Epithelium-Derived Growth Factor Stimulates HIV-1 DNA Integration and Facilitates Intasome Structural Studies.
Resolution4.67 Å
Binding residue
(original residue number in PDB)		W243 E246 G247 R263
Binding residue
(residue number reindexed from 1)		W167 E170 G171 R187
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:6u8q, PDBe:6u8q, PDBj:6u8q
PDBsum6u8q
PubMed32061936
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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