Structure of PDB 6m6b Chain M Binding Site BS01

Receptor Information

>6m6b Chain M (length=459) Species: 262724 (Thermus thermophilus HB27)

GDYLIHPEHGVGQYLGLETREVLGVKRDYLVLRYKGEGKLYLPVEQLPLL
KRHLAGRLLVLQAKRKATPGRAFPPLPEWDPLVEKGFPYELTPDQKRALE
EVLRDLESPHPMDRLVSGDVGFGKTEVALRAAHRVVGHGAQVAFLVPTTL
LAEQHGKTFRERFQGLPVRVAVLSRFTPPKEEEAILKGLAEGTVDIVIGT
HRLLQEDVRFRDLGLLIVDEEHRFGVAQKERIRELKAEVDTLYLSATPIP
RTLYSALVGLKDLSSIQTPPPGRKPIKTFLAPFDPLLVREAILFELERGG
KVFYVHDRVASIEARRRFLESLVPEARIGVVHGQMPESLIEETMLLFAEG
AYDVLLATTIIEAGLDVPEANTILIERADRLGLATLYQLRGRVGRREEEA
YAYLFHPPRLTEAAEKRLAAIADLSDLGSGHLLAERDMEIRGVGSLEVYT
ELLEEAIRK

Ligand information

>6m6b Chain T (length=28)

gggtattcgccgtagcccaaccatatgg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6m6b Structural basis of Mfd-dependent transcription termination.
• Resolution: 4.1 Å
• Binding residue (original residue number in PDB): R527 T552 H553 R554 Q557 E558 R660 V661 T711 I713 E714
• Binding residue (residue number reindexed from 1): R175 T200 H201 R202 Q205 E206 R308 V309 T359 I361 E362

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003678 DNA helicase activity
• GO:0003684 damaged DNA binding
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

Biological Process

• GO:0000716 transcription-coupled nucleotide-excision repair, DNA damage recognition
• GO:0006281 DNA repair
• GO:0006355 regulation of DNA-templated transcription
• GO:0032508 DNA duplex unwinding

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6m6b, PDBe:6m6b, PDBj:6m6b
• PDBsum: 6m6b
• PubMed: 33068413
• UniProt: Q72KB4