Structure of PDB 6gen Chain M Binding Site BS01

Receptor Information
>6gen Chain M (length=688) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVVDVPVPSLLRGNLRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQT
ISLLAYLACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLTYYGSPQ
QRKEKRKGWNKPDAFHVCIVSYQLVVQDQHSFKRKRWQYMVLDEAHNIKN
FRSTRWQALLNFNTQRRLLLTGTPLQNNLAELWSLLYFLMPQTVIDGKKV
SGFAETKKTVAKLHQVLRPYLLRRLKADVEKQMPAKYEHIVYCKLSKRQR
FLYDDFMSRAQTKATLASGNFMSIVNCLMQLRKVCNHPNLFEVRPILTSF
VLEHCVASDYKDVERTLLKLFKKNNQVNRVDLDFLNLVFTLNDKDLTSYH
AEEISKLTCVKNFVEEVNKLRETNKQLQEEFGEASFLNFQDANQYFKYSN
KQKLEGTVDMLNFLKMVNKLRCDRRPIFGKNLIDLLTKDRRVKYDKSSII
DNELIKPLQTRVLDNRKIIDTFAVLTPSAVSLDMRKLALGLNDDSSVGEN
TRLKVMQNCFEVSNPLHQLQTKLTIAFPDKSLLQYDCGKLQKLAILLQQL
KDNGHRALIFTQMTKVLDVLEQFLNYHGYLYMRLDGATKIEDRQILTERF
NTDSRITVFILSSRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRI
GQTRDVHIYRFVSEHTIESNILKKANQKRQLDNVVIQE
Ligand information
>6gen Chain I (length=173) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcattaatgcatccgcggccgccctggagaatcccggtgccgaggccgct
caattggtcgtagacagctctagcaccgcttaaacgcacgtacgcgctgt
cccccgcgttttaaccgccaaggggattactccctagtctccaggcacgt
gtcagatatatacatcctgtgca
Receptor-Ligand Complex Structure
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PDB6gen Structure and dynamics of the yeast SWR1-nucleosome complex.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		K814 R815 N831 T835 R836 M980
Binding residue
(residue number reindexed from 1)		K133 R134 N150 T154 R155 M272
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042393 histone binding
GO:0060090 molecular adaptor activity
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0000725 recombinational repair
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0000785 chromatin
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0005829 cytosol

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6gen, PDBe:6gen, PDBj:6gen
PDBsum6gen
PubMed30309918
UniProtQ05471|SWR1_YEAST Helicase SWR1 (Gene Name=SWR1)

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