Structure of PDB 6foi Chain M Binding Site BS01
Receptor Information
>6foi Chain M (length=153) Species:
9606
(Homo sapiens) [
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ATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEF
GDNTAGATSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIE
DSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLAAGVIG
IAQ
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
6foi Chain M Residue 201 [
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Receptor-Ligand Complex Structure
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PDB
6foi
Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
H63 H71 H80 D83
Binding residue
(residue number reindexed from 1)
H63 H71 H80 D83
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
H46 H48 H63 H71 H80 D83 H120 R143
Catalytic site (residue number reindexed from 1)
H46 H48 H63 H71 H80 D83 H120 R143
Enzyme Commision number
1.15.1.1
: superoxide dismutase.
Gene Ontology
Molecular Function
GO:0004784
superoxide dismutase activity
GO:0005507
copper ion binding
GO:0005515
protein binding
GO:0008270
zinc ion binding
GO:0016209
antioxidant activity
GO:0016491
oxidoreductase activity
GO:0030346
protein phosphatase 2B binding
GO:0031267
small GTPase binding
GO:0042802
identical protein binding
GO:0042803
protein homodimerization activity
GO:0046872
metal ion binding
GO:0051087
protein-folding chaperone binding
Biological Process
GO:0000302
response to reactive oxygen species
GO:0000303
response to superoxide
GO:0001541
ovarian follicle development
GO:0001819
positive regulation of cytokine production
GO:0001890
placenta development
GO:0001895
retina homeostasis
GO:0002262
myeloid cell homeostasis
GO:0006749
glutathione metabolic process
GO:0006801
superoxide metabolic process
GO:0006879
intracellular iron ion homeostasis
GO:0006915
apoptotic process
GO:0006979
response to oxidative stress
GO:0007283
spermatogenesis
GO:0007566
embryo implantation
GO:0007605
sensory perception of sound
GO:0007626
locomotory behavior
GO:0008089
anterograde axonal transport
GO:0008090
retrograde axonal transport
GO:0008217
regulation of blood pressure
GO:0008340
determination of adult lifespan
GO:0009408
response to heat
GO:0009410
response to xenobiotic stimulus
GO:0010467
gene expression
GO:0019226
transmission of nerve impulse
GO:0019228
neuronal action potential
GO:0019430
removal of superoxide radicals
GO:0032287
peripheral nervous system myelin maintenance
GO:0032930
positive regulation of superoxide anion generation
GO:0033081
regulation of T cell differentiation in thymus
GO:0035234
ectopic germ cell programmed cell death
GO:0040014
regulation of multicellular organism growth
GO:0042542
response to hydrogen peroxide
GO:0042554
superoxide anion generation
GO:0043065
positive regulation of apoptotic process
GO:0043066
negative regulation of apoptotic process
GO:0043087
regulation of GTPase activity
GO:0043410
positive regulation of MAPK cascade
GO:0043524
negative regulation of neuron apoptotic process
GO:0045471
response to ethanol
GO:0046620
regulation of organ growth
GO:0046716
muscle cell cellular homeostasis
GO:0048538
thymus development
GO:0048678
response to axon injury
GO:0050665
hydrogen peroxide biosynthetic process
GO:0050728
negative regulation of inflammatory response
GO:0050766
positive regulation of phagocytosis
GO:0051093
negative regulation of developmental process
GO:0051881
regulation of mitochondrial membrane potential
GO:0060047
heart contraction
GO:0060052
neurofilament cytoskeleton organization
GO:0060087
relaxation of vascular associated smooth muscle
GO:0060088
auditory receptor cell stereocilium organization
GO:0072593
reactive oxygen species metabolic process
GO:0099610
action potential initiation
GO:1902177
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000242
negative regulation of reproductive process
Cellular Component
GO:0005576
extracellular region
GO:0005615
extracellular space
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005737
cytoplasm
GO:0005739
mitochondrion
GO:0005758
mitochondrial intermembrane space
GO:0005759
mitochondrial matrix
GO:0005777
peroxisome
GO:0005829
cytosol
GO:0005886
plasma membrane
GO:0031410
cytoplasmic vesicle
GO:0032839
dendrite cytoplasm
GO:0032991
protein-containing complex
GO:0043025
neuronal cell body
GO:0070062
extracellular exosome
GO:1904115
axon cytoplasm
View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:6foi
,
PDBe:6foi
,
PDBj:6foi
PDBsum
6foi
PubMed
30735496
UniProt
P00441
|SODC_HUMAN Superoxide dismutase [Cu-Zn] (Gene Name=SOD1)
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