Structure of PDB 6d6r Chain M Binding Site BS01

Receptor Information
>6d6r Chain M (length=709) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDAFQR
EAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALS
NQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMRE
VAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEW
ICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNT
AMQVLRDAGSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFN
TDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPI
LKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWI
SSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSA
FHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEDIK
SAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSA
DELLLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPKLTEQLAGPLR
QMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTWATGATFAHIC
KMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKIKRD
IVFAASLYL
Ligand information
>6d6r Chain O (length=48) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tctttacggtgctcaccacaccacacacaccacaccacacaaaaaaaa
................................................
Receptor-Ligand Complex Structure
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PDB6d6r Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex.
Resolution3.45 Å
Binding residue
(original residue number in PDB)		K192 T213 G214 T217 E230 I231 M235 R238 R262 K396 G457 E483 F504 F509 S882 N917 R995 R999 E1002 Q1009
Binding residue
(residue number reindexed from 1)		K97 T118 G119 T122 E135 I136 M140 R143 R167 K284 G345 E371 F392 F397 S549 N584 R662 R666 E669 Q676
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0000460 maturation of 5.8S rRNA
GO:0006364 rRNA processing
GO:0006397 mRNA processing
GO:0006401 RNA catabolic process
GO:0006974 DNA damage response
GO:0008380 RNA splicing
GO:0016076 snRNA catabolic process
Cellular Component
GO:0000176 nuclear exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0031499 TRAMP complex
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6d6r, PDBe:6d6r, PDBj:6d6r
PDBsum6d6r
PubMed29906447
UniProtP42285|MTREX_HUMAN Exosome RNA helicase MTR4 (Gene Name=MTREX)

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