Structure of PDB 6cse Chain M Binding Site BS01

Receptor Information

>6cse Chain M (length=431) Species: 267377 (Methanococcus maripaludis S2)

WGPYMLVLLLGTGIFLTLRLGFMQIHTLPYALKLAFSKETSEGDISHFQA
LMTALAATIGTGNIAGVATAYVLGGPGAIFWMWVTAFFGMATKYAEAVLA
IKYRTVDDNGEMAGGPMYFLEKGLPLGKILGVAFAFFGAFAAFGIGNMVQ
TNSVADAVASNFGVDPLITGFVLAIFTAAVILGGIKSIGKATGIIVPFMA
VFYILAGLVILAMNIGYIIPAFGTIFSSAFNFSAGFGALIGTAIMWGVKR
GVFSNEAGLGSAPIAAAAAKTDHPGRQALVSMTGTFLDTIVVCTITGLVL
TIAGLKAFPGLTDLTGASLTAASFDALMPMGGLIVTIGLVFFAYSTVLGW
SYYGEKCFEYLIGTKGIRLYRIAFVLVAFWGATASLPLVWNIADTLNGAM
AIPNLIGLLLLSGVVVSETKAFNEIRKNEAK

Ligand information

• Ligand ID: NA
• InChI: InChI=1S/Na/q+1
• InChIKey: FKNQFGJONOIPTF-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Na+]
• Formula: Na
• Name: SODIUM ION
• DrugBank: DB14516
• PDB chain: 6cse Chain M Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6cse Structural basis for substrate binding and specificity of a sodium-alanine symporter AgcS.
• Resolution: 3.24 Å
• Binding residue (original residue number in PDB): T75 I76 N80 S274 D308
• Binding residue (residue number reindexed from 1): T58 I59 N63 S254 D288
• Annotation score: 5

Gene Ontology

Molecular Function

• GO:0005283 amino acid:sodium symporter activity
• GO:0015293 symporter activity

Biological Process

• GO:0003333 amino acid transmembrane transport
• GO:0006814 sodium ion transport
• GO:0006865 amino acid transport
• GO:0035725 sodium ion transmembrane transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:6cse, PDBe:6cse, PDBj:6cse
• PDBsum: 6cse
• PubMed: 30659158
• UniProt: Q6LX42|AGCS_METMP Sodium/alanine symporter AgcS (Gene Name=agcS)