Structure of PDB 5z3g Chain M Binding Site BS01

Receptor Information
>5z3g Chain M (length=371) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRIKKKNTRGNARNFITRSQAVRKLQVSLADFRRLCIFKGIYPREPRNKK
KANKGSTAPTTFYYAKDIQYLMHEPVLAKFREHKTFARKLTRALGRGEVS
SAKRLEENRDSYTLDHIIKERYPSFPDAIRDIDDALNMLFLFSNLPSTNQ
VSSKIINDAQKICNQWLAYVAKERLVRKVFVSIKGVYYQANIKGEEVRWL
VPFKFPENIPSDVDFRIMLTFLEFYSTLLHFVLYKLYTDSGLIYPPKLDL
KKDKIISGLSSYILESRKYDSPVASLFSAFVFYVSREVPIDILEFLILSC
GGNVISEAAMDQIDMSKVTHQIVDRPVLKNKVAGRTYIQPQWIFDCINKG
ELVPANKYLPGEALPPHLSPW
Ligand information
>5z3g Chain A (length=1501) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaau
aagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaa
gcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguugua
auuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaac
aggacgucauagagggugagaaucccguguggcgaggagugcgguucuuu
guaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugg
guggccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguac
agugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgug
aaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccu
cugcuccuuguggguaggggacgcauuucacugggccagcaucaguuuug
guggcaggauaaauccauaggaauguagcuugccucgguaaguauuauag
ccugugggaauacugccagcugggacugaggacugcgacguaagucaagg
augcuggcauaaugguuauaugccgcccgucuugaaacacggaccaagga
gucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaagguu
ggggccucgcaagaggugcacaaucgaccgauccggauuugaguaagagc
auagcuguugggacccgaaagauggugaccaucuaguagcugguuccugc
cgaaguuucccucaggauagcagaagcucguaucaguuuuaugguaagga
augaagagcuuuuagugggccauuuuuggagaacuggcgaugcgggauga
accgaacguagaguuaaggugccggaauacacgcucacaaaagguguuag
uucaucugaacuagcccugggcgcucaagcguguuaccuauacucuaccg
ucaggguugauaugaugcccugacgaguaggcaggcguggaggucaguga
cgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuug
gugguaguagcuagaucuagcgaaaccacagccaaggcuuggguuaccgc
aauaguaauugaacuuaguacgagaggaacaguucauucggauaauuggu
uuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggau
uauggcugaacgccucuaagucagaauccaugcuagaacgcggugaugcu
ccacacaaagauggauacgaauaaggcguccuuguggcgucgcugaacca
uagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcug
gcgaauugcaaugucagcguggggauaaaucauuuguauacgacuuagau
guacaacgggguauuguaagcgcugagauuaagccuuuguugucugauuu
g
..........................<<<<<<.....<......>.....
.>>>>>.>.........<<....>>..<<<<<......<<.....>>...
..>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>......
..>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......
>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>..
..>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<
<<<..>>>>>..>>>..................................<
<....>>...............<<<......>>>................
..................<<<<<.<<<<<<.....<<<<...<<<..<<<
<<<<<.......>>>>>>>>..>>>...>>>>..<<<<<<<.<<<<<<<<
<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......
>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>....
.>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<..
...<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>....<<<<
<..<<<<<....>>>>>...>>>>>.<<....<..>......>>....>>
>>>>.>>>>>...<<.<...<<<<<<.>>>>>>......>.>>..<<<<<
<......<<<....>>>..<<<<<<<<.....<<<.<<<<<<.>>>>..>
>>>>...>>>>>>.>>..<<<<.<<<....>>>.>>>>....<<<.....
.>>>...<<<<<<<..<<<<(((.....<<<<<<.......<<<.<<<<<
<<<<..>>>>>>>>>>>>.)))......>>>>>>.>>>>..>>>>>>><<
<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<<.<<..
....<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>
>><<.....<<<<<..>>>>>....>>....<<<<<.>>>>>.<<<<<<<
..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<
....<<<<<<<<<......>>>>..>>>>>...>>>>..>>>>>.<<<<.
..<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>..<<
<<<<........<<..........<<<<<<.....>>>>>>......>>.
......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>
>>................>>>>>>.<<<<<<.<..<.......>..>...
..<<<<<.<<<.<<.....<..>....>>....>>>..>>>>>..>>>>>
>
Receptor-Ligand Complex Structure
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PDB5z3g Cryo-EM structure of an early precursor of large ribosomal subunit reveals a half-assembled intermediate.
Resolution3.65 Å
Binding residue
(original residue number in PDB)		R88 K89 T91 R92 G95 R104
Binding residue
(residue number reindexed from 1)		R88 K89 T91 R92 G95 R104
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0030687 preribosome, large subunit precursor
GO:0070545 PeBoW complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5z3g, PDBe:5z3g, PDBj:5z3g
PDBsum5z3g
PubMed29557065
UniProtP53261|PESC_YEAST Pescadillo homolog (Gene Name=NOP7)

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