Structure of PDB 4kzx Chain M Binding Site BS01

Receptor Information

>4kzx Chain M (length=124) Species: 9986 (Oryctolagus cuniculus)

GGVMDVNTALQEVLKTALIHDGLARGIREAAKALDKRQAHLCVLASNCDE
PMYVKLVEALCAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRKVVGCSC
VVVKDYGKESQAKDVIEEYFKCKK

Ligand information

>4kzx Chain i (length=1797)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccucuccuacuuggauaa
cugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugu
gugggaugcgugcauuuaucagaucaaaaccaacccggucagccuccccg
ccggccggggggguggggcggcggcuuuggugacucuagauaaccucggg
ccgaucgcagcccuccguggcggcgacgacccauucgaacgucugcccua
ucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacg
gggaaucaggguucgauuccggagagggagccugagaaacggcuaccaca
uccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagg
uagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauugga
augaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucug
gucgcagcagccgcgguaauuccagcuccaauagcguauauuaaaguugc
ugcaguuaaaaagcucguaguuggaucuuggagggugcguagcgggccac
cgcccguccccgccuugccuccgaagcguuuacuuugaaaaaauuagagu
guucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaa
uaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaa
gagggacggccgggggcauucguauugcgccgcuagaggugaaauucuug
gaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuuca
uuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucgua
guuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccau
gacccgccgggcagcuuccgggaaaccaaagucuuuggguuccgggggga
guaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacca
ggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccgg
cccggacacggacaggauugacagauugauagcucuuucucgauucugug
ggugguggugcauggccguucuuaguugguggagcgauuugucugguuaa
uuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccg
agcggucggcgucccccaacuucuuagagggacaaguggcguucagccac
ccgagauugagcaauaacaggucugugaugcccuuagaugucggggcugc
acgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcagg
cgcggguaacccguugaaccccauucgugauggggaucggggauugcaau
uauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcg
uugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauu
ggaugguuuagugaggcccucggaucggcccgccggggucggcccacggc
ccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaagua
aaagucguaacaagguuuccguaggugaaccugcggaaggaucauua

...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[....................<<.....
<<.<<<.....>>>.>>......>>.........<<<...<<.<......
>.>>...>>>.[[..(((((.....<<<<<<<<<<<<.<...<.<<<...
.......>..>.>.>.....>>>>..............)))))......]
]...<<<<.<<<......>>>.>>>>....]]]...}}....]]].<<<.
...<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<
<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.
<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>
>......}}.......<<<<<<<<<.<<<....>>>.>.>>>>>.>>>..
....<<..<...........>..>>.........<<<<<((......<<<
<.....<<..))>>.......>>>>.>>>>>..)))))).]]].......
.....{{.......{{...[[[.[[.......<<<...<..<........
>..>...>>>......<<.<...>.>>..<<<<<..<.......<<...<
.......>.<<<<.......>>>>...>>......>..>>..>>>.....
..[[....(((((((.....>>>>>>>>>.)))))))...]]....]]..
..<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>...
...>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>.
..]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...
>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>
>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<..
....<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..
<<<<<..<<<.<<<<<<......<<........>>..........<<<<<
......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>
.<.<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<....
..>>>...>>.>>>....<<<...<...<<<<..<<<<....<<<..<<<
<....>>>>.>>>....>>>>..>>>>..>.....<<<<<.....>>>>>
........>>>....>>>.>>>...>.>>>>>>>>.....>>>>>...>>
.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>
>>.>>>....>.........>>>.>>............<<<<<.......
...>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>
>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....
<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<.....>>>>
>>>>>>.>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>
...>.>>.........<<<<<<<<<....>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4kzx The initiation of mammalian protein synthesis and mRNA scanning mechanism.
• Resolution: 7.809 Å
• Binding residue (original residue number in PDB): R33 G34 I35 R36 E37 K40 D57 E58 Y61 C106 S107
• Binding residue (residue number reindexed from 1): R25 G26 I27 R28 E29 K32 D49 E50 Y53 C98 S99

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation
• GO:0042274 ribosomal small subunit biogenesis
• GO:0090263 positive regulation of canonical Wnt signaling pathway

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005794 Golgi apparatus
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0032040 small-subunit processome
• GO:0043231 intracellular membrane-bounded organelle
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4kzx, PDBe:4kzx, PDBj:4kzx
• PDBsum: 4kzx
• PubMed: 23873042
• UniProt: G1SFR8|RS12_RABIT Small ribosomal subunit protein eS12 (Gene Name=RPS12)