Structure of PDB 4k4z Chain M Binding Site BS01

Receptor Information

>4k4z Chain M (length=462) Species: 12072 (Coxsackievirus B3)

GEIEFIESSKDAGFPVINTPSKTKLEPSVFHQVFEGNKEPAVLRSGDPRL
KANFEEAIFSKYIGNVNTHVDEYMLEAVDHYAGQLATLDISTEPMKLEDA
VYGTEGLEALDLTTSAGYPYVALGIKKRDILSKKTKDLTKLKECMDKYGL
NLPMVTYVKDELRSIEKVAKGKSRLIEASSLNDSVAMRQTFGNLYKTFHL
NPGVVTGSAVGCDPDLFWSKIPVMLDGHLIAFDYSGYDASLSPVWFACLK
MILEKLGYTHKETNYIDYLCNSHHLYRDKHYFVRGGMPSGCSGTSIFNSM
INNIIIRTLMLKVYKGIDLDQFRMIAYGDDVIASYPWPIDASLLAEAGKG
YGLIMTPADKGECFNEVTWTNVTFLKRYFRADEQYPFLVHPVMPMKDIHE
SIRWTKDPKNTQDHVRSLCLLAWHNGEHEYEEFIRKIRSVPVGRCLTLPA
FSTLRRKWLDSF

Ligand information

>4k4z Chain N (length=17)

ccaggucucucgucgaa

.................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4k4z Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts.
• Resolution: 2.17 Å
• Binding residue (original residue number in PDB): N18 P20 K22 K24 E108 T114 S115 K127 Y157 K159 I176 A178 R188 H199 G211 C212 D213 G290 C291 S292 R416 L420
• Binding residue (residue number reindexed from 1): N18 P20 K22 K24 E108 T114 S115 K127 Y157 K159 I176 A178 R188 H199 G211 C212 D213 G290 C291 S292 R416 L420

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.28: picornain 3C.
  3.4.22.29: picornain 2A.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:4k4z, PDBe:4k4z, PDBj:4k4z
• PDBsum: 4k4z
• PubMed: 23667424
• UniProt: Q5UEA2