Structure of PDB 4c3e Chain M Binding Site BS01

Receptor Information
>4c3e Chain M (length=155) Species: 11259 (Human respiratory syncytial virus A2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RNPCKFEIRGHCLNGKRCHFSHNYFEWPPHALLVRQNFMLNRILKSMDRT
EEYALGVVGVLESYIGSINNITKQSACVAMSKLLTELNSDDIKKLRDNEE
LNSPKIRVYNTVISYIESNRKNNKQTIHLLKRLPADVLKKTIKNTLDIHK
SITIN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4c3e Chain M Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4c3e Crystal Structure of the Essential Transcription Antiterminator M2-1 Protein of Human Respiratory Syncytial Virus and Implications of its Phosphorylation.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		C7 C15 C21 H25
Binding residue
(residue number reindexed from 1)		C4 C12 C18 H22
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0019083 viral transcription
GO:0031564 transcription antitermination
GO:0046782 regulation of viral transcription
GO:0085033 symbiont-mediated activation of host NF-kappaB cascade
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4c3e, PDBe:4c3e, PDBj:4c3e
PDBsum4c3e
PubMed24434552
UniProtP04545|M21_HRSVA Protein M2-1 (Gene Name=M2-1)

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