Structure of PDB 1p7h Chain M Binding Site BS01

Receptor Information
>1p7h Chain M (length=286) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSVPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPV
VQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKI
VGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRV
RLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYG
GQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEI
PEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1p7h Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa B element
Resolution2.6 Å
Binding residue
(original residue number in PDB)		R421 R430 R537 Q571
Binding residue
(residue number reindexed from 1)		R29 R38 R145 Q179
Binding affinityPDBbind-CN: Kd=20nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1p7h, PDBe:1p7h, PDBj:1p7h
PDBsum1p7h
PubMed12949493
UniProtQ13469|NFAC2_HUMAN Nuclear factor of activated T-cells, cytoplasmic 2 (Gene Name=NFATC2)

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