Structure of PDB 1owr Chain M Binding Site BS01

Receptor Information
>1owr Chain M (length=284) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQ
LHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVG
NTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRL
VFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQ
QMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPE
YRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1owr Structure of NFAT Bound to DNA as a Monomer
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R421 G428 S429 R430 I479 R537 Q571 R665
Binding residue
(residue number reindexed from 1)		R27 G34 S35 R36 I85 R143 Q177 R271
Binding affinityPDBbind-CN: Kd=2.7nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1owr, PDBe:1owr, PDBj:1owr
PDBsum1owr
PubMed14643663
UniProtQ13469|NFAC2_HUMAN Nuclear factor of activated T-cells, cytoplasmic 2 (Gene Name=NFATC2)

[Back to BioLiP]