Structure of PDB 1j5a Chain M Binding Site BS01

Receptor Information
>1j5a Chain M (length=58) Species: 1299 (Deinococcus radiodurans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKHPVPKKKTSKSKRDMRRSHHALTAPNLTECPQCHGKKLSHHICPNCGY
YDGRQVLA
Ligand information
>1j5a Chain A (length=2774) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaug
aaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuug
acucggggauguccgaauggggaaacccaccucguaagagguauccgcaa
ggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaa
gagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaag
auucaaccccucaagccgaaguggcuggaaagcuacaccucagaagguga
gaguccuguaggcgaacgagcgguugacuguaaguaggucguuguucgug
aaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacuccca
gugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccggg
aggggagugaaagagaaccugaaaccguggacuuacaagcagucauggca
ccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuaga
ccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguc
cgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcu
aagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccg
gugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcua
accgaaccuggagauagcuaguucuccccgaaauguauugagguacagcc
ucggauguugaccauguccuguagagcacucacaaggcuagccaaaccuu
augaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagag
cuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucc
cuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccagg
agguuggcuuagaagcagccacccuucaaagagugcguaauagcucacug
gucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaa
gcuauggauucaacucgcgaagcgaguugucugguaggggagcguucagu
ccgcggagaagccauaccggaaggagugguggagccgacugaagugcgga
ugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaagg
acaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaa
ggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcac
cgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcu
auggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuac
cggucacaugccucagacguaucgggagcuuccucggaagcgaaguugga
aacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccg
uaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcga
gagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaaga
agggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacug
uuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggu
gugacgccugcccggugccggaaggucaaguggagcggugcaagcugcga
aaugaagccccggugaacggcggccguaacuauaacgguccuaagguagc
gaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucu
gggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagau
gcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagu
cuggcauugggauucggguuucucugcguaggugggagaaacuggccggu
cgguggccacccugagaaacuuggauuucuaaccugaaaaaucacuuucg
gggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaaug
uaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguag
agcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagg
gaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucg
aucaacggauaaaaguuaccccggggauaacaggcugaucucccccgaga
guccauaucggcggggagguuuggcaccucgaugucggcucgucgcaucc
uggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggc
acgcgagcuggguucagaacgucgugagacaguucggucucuauccgcua
cgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggag
ugaacggaccgcuggucucccugcugucguaccaacggcacaugcagggu
agcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccag
ccccaagaugaguucucccacuguucagguaagacucccggaagaccacc
ggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggu
gcucaucagucgaggucuugacca
<<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<....
..<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>....
..>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....
>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........
<<....>>...<<<<......<<.....>>.....>>>>...<<<...<.
<.<<<<<<..<<..<<<...<<<<<......>>>>>((......<<<...
..))>>>...>>>....>.>.>>>>>>.>.>.....<<<<<<<<<.....
..>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>
>>>.>>..............<<....>>....>>.........<<<<...
.>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<
<.......>>>>>>>>>>...<.<........>.>..<<<<<....<<<.
<<<<<<<<<<...<.................>.....<<....>>...<<
.......>>........>>>>>>>>>>>>>..<<.<...<<<<<<.....
<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<
..<.<<........>>.>.>>>....>>>>>>>>>...<<<.....>>>.
.....>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<
<<<<<<...<..<.<<<<<<...<<<...<<<.<<<<.........>>>>
.>>>..>>.>...>>>>>>.>...>..>>>>>>>.>>..<<<<<<<.<<.
.....>>.>>>>>>>....<<<......>>>....<...<<<...<<<((
(.....<<<<<<...........<<..<<<<<<<<..........<<<<.
<<<...<<<.......>>>...>>>.........<<......>>...>>>
>......>>>>>>>>.>>..........)))......>>>>>>.>>>...
>>>...>...<<<<<<<<...>>>>>>>>.......>>>>>><<<<<<<<
<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>.>>....
.>>>>>........<<.....<<<<<<.......>>>>>><<<<....<<
<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...
<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))
<<<<<<<<<...<<...<<<.....<<<<..<<<..<<<<<.<<<<.<<.
..[[....>>>>>>.<...<<.<..<<<.<<<<<<<.............>
>>>>>....>>>>..>.>>..>.....<<<<.....>.>>>....>>>>>
...>>>...>>>>..........>>>...>>......>>>>>>>>>>>>>
..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<
<....<<<<<<<<.<<...............<<<<<..............
.>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<
...........>>..<<<<<<<.....<<<.....>>>.......>>>>>
>>.<<<<<.<<<..<<<<<<<..<<<...<......<.......>.....
..>...>>>>>>>>..>>>>>...<<.........>>...........<.
..........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>
>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<.......
.>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<..<<
<.<<<<..<<<..<.<<<..<<<<.<....<<<.........<.......
.>......>>>>.>>>>..>>>..>.>>.>..<<<<............>>
>>.....>>>>.>>>...>>>>..<<<<.....>>>><<<<<<.......
....>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>....
.<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.
<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>
.............>>>>..>>>>>>.......<<<<.<.<<<<<<.<.<<
.......>>..>>>>>>>...>>>>.>.......<<<<<.<.<<<...<<
<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>......>>>.
..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>
>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>
>>>.<<<<<....<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>..
.>>>..>>>>>....<<....<<<<<...........>>>>>....>>..
>>>>.......>>>>>>>..<<<..>>>....<<<<<<<<<.......>>
>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>
.>>>...>>>>....>>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1j5a Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria.
Resolution3.5 Å
Binding residue
(original residue number in PDB)
H4 P7 K10 H43
Binding residue
(residue number reindexed from 1)
H3 P6 K9 H42
Binding affinityPDBbind-CN: Kd=10nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:1j5a, PDBe:1j5a, PDBj:1j5a
PDBsum1j5a
PubMed11677599
UniProtP49228|RL32_DEIRA Large ribosomal subunit protein bL32 (Gene Name=rpmF)

[Back to BioLiP]