Structure of PDB 8pv6 Chain Lq Binding Site BS01

Receptor Information
>8pv6 Chain Lq (length=139) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNVSADLIWEVSRNYNSFLVKQRTGTFSRDALNLTNQHSRKHAGFVNDKA
LGIVPAEKGVKVIAKKVKAANKPASSLYTVTYKSTARKAYKAIASQAAKH
GYRADLRQAAVARASAILRSQRPVKPEPPKKLRGAAARR
Ligand information
>8pv6 Chain C1 (length=3100) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agguugaccucggaucagguaggaggacccgcugaacuuaagcauaucaa
uaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgaguga
agcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuu
ggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacg
ccacagagggugagagccccguauaguuggaagccaagccuguguaaagc
uccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaa
auuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguaga
gugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacguga
aauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucau
ccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucu
ggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauag
cccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggau
gcuggcguaauggucaccagcgacccgucuugaaacacggaccaaggagu
caagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaag
ugaacguaggugagagcuucggcgcaucaucgaccgauccugauguauuc
ggauggauuugaguaggagcguuaagccuuggacccgaaagauggugaac
uaugcuuggauagggugaagccagaggaaacucugguggaggcucgcagc
gguucugacgugcaaaucgaucgucaaaucugagcaugggggcgaaagac
uaaucgaaccaucuaguagcugguuaccgccgaaguuuccggauagcagu
gucgaccuucaguuuuaugagagcgaaugauuagggacucgggggcgccu
ucauccauucucuguaagaagcccuuguuacuuaacugaacgugggcgaa
ugucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggau
gaaccgaacgcgggguuaaggugccggaguggacgcucaucagacaccac
aaaaggcguuaguacaucuugacagcaggacgguggccauggaagucgga
auccgcuaaggacuguguaacaacucaccugccgaauguacuagcccuga
aaauggauggcgcucaagcgucccacccauaccccgcccucaggguagaa
acgaugcccugaggaguaggcggccguggaggucagugacgaagccuagg
gcgugagcccgggucgaacggccucuagugcagaucuuggugguaguagc
aaauacuucaaugagaacuugaaggaccgaaguggggaaagguuccaugu
gaacagcgguuggacauggguuagucgauccuaagccauagggaaguucc
guuucaaaggggcacucgugccccgggcgaaagggaagccgguuaauauu
ccggcaccuggauguggguuuugcgcggcaacgcaacugaacgcggagac
gacggcgggggccccgggcagaguucucuuuucuucuuaacggucuauca
cccuggaaacaguuugucuggagauaggguuuaauggccggaagagcccg
acacuucugucggguccggugcgcucucgacgucccuugaaaauccgcgg
gagggaauaauucucacgccaggucguacucauaaccgcagcaggucccc
aaggugaacagccucugguugauagaacaauguagauaagggaagucggc
aaaauagauccguaacuucgggaaaaggauuggcucuaaggguugggcac
gugcgugcgguuaacaaccaacuuagaacugguacggacagggggaaucu
gacugucuaauuaaaacauagcauugcgauggccagaaagugguguugac
gcaaugugauuucgcccagugcucuaugucaaagugaagaaauucaacca
agcgcggguaaacggcgggaguaacuaugacucucuuaagguuaacgaga
uucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgg
gcuuggcaaaaucagcggggaaagaagacccuguugagcuugacucuagu
uugacauugugaaaagacauaggagguguagaauaggugggagcuucggc
gccagugaaauaccacuacuccuauuguuuuuuuacuuauucaaugaagc
ggggcuggacuugcguccaacuucuggaguuaagguccuucgcgggccga
cccggguugaagacauugucagguggggaguuugggcacaucugcaggug
uccuaaggggggcucauggagaacagaaaucuccaguagaacaaaagggu
aaaaguccccuugauuuugauuuuugugaauacaaaccaugaaagugugg
ccccuuuagucccucgaaauuugaggcuagaggaaguuaccacagggaug
gcuuguggcggccaagcguucauagcgacgucgcuuugauccuucgaugu
cggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguac
ccacuaauagggaacgagcuggguuuagaccgucgugagacagguuaguu
uuacccuacugaugaacucgucgcaaugguaauucagcuuaguacgagag
gaaccgcugauucagauaauugguuuuugcgguuguccgaccgggcagug
ccgcgaagcuaccaucugcuggauaauggcugaacgccucuaagucagaa
uccaugccagaacgcgacgauacuacccgcacguuguagacguauaagaa
uaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaag
uggccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaau
ccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagagua
gccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuuc
...........................<<<<<<.....<......>....
..>>>>>.>...<.....<<....>>..<<<<<......<<.....>>..
...>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>.
...<<<<<.<<<<<<<<<..<<<<<<..<<<...<<<<......>>>>.(
(......<<<.....))>>>.>..>>..>>>.>>>..>>>>....>>>>>
>>>.>>........<<<<<<<........>>>>>>>.....<<<<<..((
((((>>>>>..>>>....>.............................<<
....>>...............<<<<....>>>>.................
.................<<<<.<<<<<<.<...<<.<<<<<<<<<.....
<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<
<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......
>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>
>>>>>>....>>>>>>>.>>>>..<<<<........>>>><<<<<<...<
<<<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>
>.......<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>
>...>>>>.>>.>>....>>>>.>>>>>>>>>.<<.<...<<<<<<....
.<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<
<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>
>......>>>>>>......>.>>...<<<<<......<<..>>..<<<<<
<<<<.....<<.<<<<<<<.........<<....<<<...<<<<<..>>>
>>.>>>..>>..>>>>>...<<<<.<<<<.<......>>>>>.>>>>.>>
>>.>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<...
...>>>...<<<<<<<...<<<(((.....<<<<<<.....<<.......
...<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>.
..>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..
........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<....
.....>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<
<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<
.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<
...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<....>>>
........<<<<<......>>>>>.>>>....>>...<<<<<........
>>>>>))<<<<.<<<<.<<<....<<<....>>>...<..{<<<<<<...
<<<<.<<<<<<<.<<<<<.<<<<...[[..>>>>.><...<<<<<....<
<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<
<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>.
..>.....>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>
.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........
<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.<<<<
<..>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<
<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......
>>>>>>>......<<<..<<<<<<..<<<.....<<<<....>>>>....
.>>>.>>>>..>>>>><<<<<<.......>>>>>>..........>>.>>
>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<.......
.>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<
<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>
............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<
<<<..<<<<<....>>>>>..........}...<<<<<.....>>>>>..
>>>>..>>>>>.....>>>>>>>>..>>>>>...<<.<<<<<<..>>>>>
>>>...<<<<<<<...<<<<<<.......>>>>>>.....<<....((>>
....>>>>>>>...<<<.<<<<<....>>>>.>>>>.<<<....>>>...
))<<<<<<<..<<<<.))))))>>>>>>>>>>>.>>>>..>>>>>>>...
......<<<<<<...<<.......>>...>>>>>>...............
<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<.<...>.
>>>.....>>>>.....>>>>......<<<<<<<....>>>.>>>>....
....>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<............
.....>>>>>.><<<<<...<<<<....<<<<<<<<<<]]..>>>>>..>
>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...
>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<......<<.....
..<<<....>>>....>>........<<<<.....<<<.<<<<<......
.>>>>>.>>>....>>>>..............>>>>>.>>>>>...<<<<
<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<
<<......>>>>>...>>>>...>>>....>>>>..>>>>>...>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8pv6 Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.
Resolution2.94 Å
Binding residue
(original residue number in PDB)		W10 R14 Y16 S18 K22 R24 R30 H39 R41 K42 K67 Y79 V81 Y83 K84 R88 K89 K92 S96 Q97 H101 Y103 R104 A105 D106 R108 K126 K132 R134 A136
Binding residue
(residue number reindexed from 1)		W9 R13 Y15 S17 K21 R23 R29 H38 R40 K41 K66 Y78 V80 Y82 K83 R87 K88 K91 S95 Q96 H100 Y102 R103 A104 D105 R107 K125 K131 R133 A135
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8pv6, PDBe:8pv6, PDBj:8pv6
PDBsum8pv6
PubMed37921038
UniProtG0SHJ6

[Back to BioLiP]