Structure of PDB 8oo0 Chain Lq Binding Site BS01

Receptor Information
>8oo0 Chain Lq (length=141) Species: 209285 (Thermochaetoides thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNVSADLIWEVSRNYNSFLVKQRTGTFSRDALNLTNQHSRKHAGFVNDKA
LGIVPAEKGVKVIAKKVKAANKPASSLYTVTYKSTARKAYKAIASQAAKH
GYRADLRQAAVARASAILRSQRPVKPEPPKKLRGAAARRAA
Ligand information
>8oo0 Chain 1 (length=3191) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guugaccucggaucagguaggaggacccgcugaacuuaagcauaucaaua
agcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaag
cggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuugg
agaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgcc
acagagggugagagccccguauaguuggaagccaagccuguguaaagcuc
cuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaau
uucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagu
gaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaa
uuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucaucc
gguguucucaccggugcacuccgccgggcucaggccagcaucgguucugg
cggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcc
cuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugc
uggcguaauggucaccagcgacccgucuugaaacacggaccaaggaguca
agguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaagug
aacguaggugagagcuucggcgcaucaucgaccgauccugauguauucgg
auggauuugaguaggagcguuaagccuuggacccgaaagauggugaacua
ugcuuggauagggugaagccagaggaaacucugguggaggcucgcagcgg
uucugacgugcaaaucgaucgucaaaucugagcaugggggcgaaagacua
aucgaaccaucuaguagcugguuaccgccgaaguuucccucaggauagca
gugucgaccuucaguuuuaugagguaaagcgaaugauuagggacucgggg
gcgauuuuuagccuucauccauucucaaacuuuaaauauguaagaagccc
uuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggcc
auuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguua
aggugccggaguggacgcucaucagacaccacaaaaggcguuaguacauc
uugacagcaggacgguggccauggaagucggaauccgcuaaggacugugu
aacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaag
cgucccacccauaccccgcccucaggguagaaacgaugcccugaggagua
ggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaa
cggccucuagugcagaucuuggugguaguagcaaauacuucaaugagaac
uugaaggaccgaaguggggaaagguuccaugugaacagcgguuggacaug
gguuagucgauccuaagccauagggaaguuccguuucaaaggggcacucg
ugccccguguggcgaaagggaagccgguuaauauuccggcaccuggaugu
ggguuuugcgcggcaacgcaacugaacgcggagacgacggcgggggcccc
gggcagaguucucuuuucuucuuaacggucuaucacccuggaaacaguuu
gucuggagauaggguuuaauggccggaagagcccgacacuucugucgggu
ccggugcgcucucgacgucccuugaaaauccgcgggagggaauaauucuc
acgccaggucguacucauaaccgcagcagguccccaaggugaacagccuc
ugguugauagaacaauguagauaagggaagucggcaaaauagauccguaa
cuucgggaaaaggauuggcucuaaggguugggcacguugcggcgugcggu
uaacaaccaacuuagaacugguacggacagggggaaucugacugucuaau
uaaaacauagcauugcgauggccagaaagugguguugacgcaaugugauu
ucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggg
uaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucguc
aucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccu
aucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaauca
gcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaa
agacauaggagcuccuauuguuuuuuuacuuauucaaugaagcggggcug
gacuugcguccaacuucuggaguuaagguccuucgcgggccgacccgggu
ugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaa
ccauaacgcagguguccuaaggggggcucauggagaacagaaaucuccag
uagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauac
aaaccaugaaaguguggccuaucgauccuuuagucccucgaaauuugagg
cuagaggugccagaaaaguuaccacagggauaacuggcuuguggcggcca
agcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccua
ucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauag
ggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccua
cugaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcu
gauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaag
cuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugcc
agaacgcgacgauacuacccgcacguuguagacguauaagaauaggcucc
ggccucguauccuagcaggcgauuccuccgccggccucgaaguggccguc
gguaauucgcguauugcaauuuagacacgcgcgggaucaaauccuuugca
gacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguu
guuacgaucugcugaggguaagcccuccuucgccuagauuu
.........................<<<<<<.....<......>......
>>>>>.>.........<<....>>...<<<<......<<.....>>....
.>>>>...[[[..<<.......<<.<<<....>>>.>>.......>>...
.<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((.
.....<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>
>.>>........<<<<<<<........>>>>>>>.....(((((.<<<<<
<<)))))..]]]..................................<<..
..>>...............<<<<....>>>>...................
...............<<<<.<<<<<<.....<<.<<<<<<<<<.....<<
<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<
<<<<<<.....<.<<<<<<<<......<<<<<....>>>>>.......>>
>>>>>>....>.>>>>>>>>>>>>>>>........<<...>>.....>>>
>>>>.....>>>>>>.>>>>..<<<<........>>>><<<<<<....<<
<<<<<<.<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.
......<<<<<..<<<..>>>...>>>>>.<<<<<<<<...<<....>>.
..>>>.>>>.>>....>>>>.>>>>>>>>..<<.<...<<<<<<.....<
<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<.
.<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>.
.....>>>>>>......>.>>...<<<<<....<.<<<....>>>.><<<
<<<<<<.....<<.<<<<<<<.....<<<....<<<....<<<...<<<<
<<........>>>>>>.>>>....>>>..>>.>.....>>>>>...<<<<
.<<<<.<......>>>>>.>>>>.....>>>>...>>>>>>>.>>..<<<
<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..
.<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.
......<<<<<.<<<...<<.........>>...>>>.........<<..
....>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>
>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....
>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>
>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......
>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>
>....((<<<<<<...<<<...<<<....>>>........<<<<<.....
.>>>>>....>>>....>>...<<<<<........>>>>>))<<<<.<<<
<.<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<
<<<.<<<<.......>>>>.><...<<<<<....<<<<<<....<<<...
..>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>
>>>>...>>>>>>>.>>>>.........>>>>>>.........>>>...>
>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.
.>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....
<<..>>.....>>>>><<.<<<<<<<<<<<.<<<<<<....>>>>>>...
...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.....
....>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<
<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>
>..>>>>>.<<<<<.......>>>>>.........<...........<<<
<<.......>>>>>.....>.....>>.>..>>.>>>>>>>..>..>>.>
>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[
[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<
<<<<<<<<<<..>>>>>.>>>>>>>>>>>...<<<<<.....<<<<..<<
<<<....>>>>>..............<<<<<.....>>>>>..>>>>..>
>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<....
.......>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.
....<<...(((>>....>>>>>>>...<<.<<<<<<.......>>>>.>
>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>>)))
))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<..
.<<.......>>...>>>>>>...>>.>.>.......<<<<<..<<<<<.
.<.<<<<<<<......>>>>>>..>.>.<<<.........>>>.....>>
>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.
]]]]]....<<<<<<<..<<<<.<.<<<<<.................>>>
>>.><<<<<...<<<<....<<<<<<<<<<....>>>>>..>>>>>...>
>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>
>....>>>>>>>.....<<<<<.<..<<<......<<.......<<<<..
>>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>
>>....>>>>..............>>>.>.>>>>>...<<<<<<<.....
........>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......
>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8oo0 Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.
Resolution3.1 Å
Binding residue
(original residue number in PDB)
R14 Y16 R24 R30 H39 S40 K42 K67 Y79 Q97 K100 H101 Y103 A105 D106 R134 R139
Binding residue
(residue number reindexed from 1)
R13 Y15 R23 R29 H38 S39 K41 K66 Y78 Q96 K99 H100 Y102 A104 D105 R133 R138
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8oo0, PDBe:8oo0, PDBj:8oo0
PDBsum8oo0
PubMed38267453
UniProtG0SHJ6

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