Structure of PDB 7bhp Chain Lp Binding Site BS01

Receptor Information
>7bhp Chain Lp (length=72) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRA
VGIWHCGSCMKTVAGGAWTYNT
Ligand information
>7bhp Chain L5 (length=3644) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacau
guggcguacggaagacccgcuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccggaggauucaacccggcggcggguccggccgugucggcgg
cccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggc
cgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccggg
acggcugggaaggcccggcggggaagguggcucgggggcccccgaguguu
acagcccccccggcagcagcacucgccgaaucccggggccgagggagcga
gacccgucgccgcgcucuccccccucccggcggggggggccgggccaccc
cucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggc
gggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgagggg
gacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccg
acccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggg
gcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcuc
gccggccgaggugggaucccgaggccucuccaguccgccgagggcgcacc
accggcccgucucgcccgccgcgccggggagguggagcacgagcgcacgu
guuaggacccgaaagauggugaacuaugccugggcagggcgaagccagag
gaaacucugguggagguccguagcgguccugacgugcaaaucggucgucc
gaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuc
ccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacccgc
cacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaa
gaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcug
gcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaa
gcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgau
gccgacgcucaucagaccccagaaaagguguugguugauauagacagcag
gacgguggcaagucgcuaaggagguguaacaacucaccugccgaaucaac
uagcccugaaaauggauggcgcuggagcgucgggcccauacccggccguc
gccggcagucgagaguggacgggagcgggcggcgcgccgcgcccggagcc
ccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuug
aagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggu
gguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaagg
guuccaugugaacagcaguugaacaugggucagucgguccugagagaugg
gcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccg
aucgaaagggagucggguucagauccccgaauccggaguggcggagaugg
gcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccgg
cgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccu
ggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgg
uuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggag
aggguguaaaucucgcgccgggccguacccauauccgcagcaggucucca
aggugaacagccucuggcauguuggaacaauguagguaagggaagucggc
aagccggauccguaacuucgggauaaggauuggcucuaagggcugggucg
gucgcggccggcgccuagcagccgacuuagaacuggugcggaccagggga
auccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcgggugu
ugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaau
ucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaaggua
gccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgag
auucccacugucccuaccuacuauccagcgaaaccacagccaagggaacg
ggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuag
ucuggcacggugaagagacaguuuuuucacugacccggugaggcgggggg
gcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgc
cggccgggcgcgacccgcuccggggacagugccagguggggaguuugacu
ggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcuca
gggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugauc
uugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuu
cugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacaggga
uaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugaucc
uucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguug
gauuguucacccacuaauagggaacgugagcuggguuuagaccgucguga
gacagguuaguuuuacccuacugaugauguguuguugccaugguaauccu
gcucaguacgagaggaaccgcagguucagacauuugguguaugugcuugg
cugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacg
ccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcgga
gccucgguuggccucggauagccggucccccgccgggguccggugcggag
ugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccu
cgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucg
uagacgaccugcuucugggucgggguuucguacguagcagagcagcuccc
ucgcugcgaucuauugaaagucagcccucgacacaaggguuugu
.........................<<<<<<.....<<....>>......
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................<<....>>...............<<<<....>>>
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.<<<<...<<..<<<.<<.<<<<......<<<<<<<....>>>>>>>...
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...........<<<<<<.<<<<<...........>>>>>.<<<<<<.<<<
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<<<........>>>>.....>>>...<<....>>...<<<<<<.......
.>>>>>>..<<<<<...<<<..<<<.......(((.>>>..>>>....>>
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>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<
....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>..
..>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<
<<<<<....<.<<<....>>>.><<.<<<<<<<.................
...<<<.<<<<<<<<<...<<<....<<<..<.<<<....<<<<......
..>>>>..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<....
.....>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<....
.>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((....
...<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<
.....................................>>>>...>>>>>>
>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<
<<.<<<...........)))..............................
.............>>>>>>>>>....>>>>>>...<<<<<<<<.<<....
..<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.........>>>>>
<<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<
...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<
<<....>>>..........<<.<<<<<<<<.....>>>>>>>>>>.....
.>>....>>...<<<<<........>>>>>))<<<<....<<<<<..<<<
<<<<<....>>>>>>>>..<<<....>>>......<<<<<<<...<<<<<
<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<
.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<..
.....>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>...
..........>>.>>>.>>>>>>>>..>>.....<<......>>>>>>>.
<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........
<.....<<<<<...............>>>>><<.<<<<<<<<<<<.....
..................>>>>>..>>>>>>.>>............<<<<
<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>..
....>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>
>>>.....>>>.>>>>..>>>>>.<<<<.........>>>>.........
<...........<<<<<.......>>>>>.....>.....>>....>>.>
>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<......
..>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<
<<<<<<<<.<<<<<<<.......>>>>>>>...<<<<<.....<<<<...
.....<<......>>...................<<<<<<<<<<......
.>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<
.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...
<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<
<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<
<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>..
.....<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>
.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<
<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....
>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<....<<<
<<.................>>>>>..<<<<....<<<<...<<<.<<<<<
<<]]].>>>>>..>>.>>>..>>>>...>>>><<<<....<<<<<.....
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.<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>......
.>>>...<<<...<<<....<<<<.<<<<<<<......>>>>>>>>>>>.
..>>>...>>>..............>>>>..>>>>>>>>><<<<<.<...
..........>....<<.<<<<<<<.<<.....<<<<....<<<<<....
..>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7bhp Dynamic association of human Ebp1 with the ribosome.
Resolution3.3 Å
Binding residue
(original residue number in PDB)
A2 K3 R4 T5 K6 K7 V8 G9 I10 K13 Y14 T16 R17 Y18 G19 A20 S21 R23 H34 C42 K44 R50 A51 K62
Binding residue
(residue number reindexed from 1)
A1 K2 R3 T4 K5 K6 V7 G8 I9 K12 Y13 T15 R16 Y17 G18 A19 S20 R22 H33 C41 K43 R49 A50 K61
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7bhp, PDBe:7bhp, PDBj:7bhp
PDBsum7bhp
PubMed33479117
UniProtP61513|RL37A_HUMAN Large ribosomal subunit protein eL43 (Gene Name=RPL37A)

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