Structure of PDB 8g60 Chain Lo Binding Site BS01 |
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| >8g60 Chain L5 (length=3637)
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cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacau
guggcguacggaagacccgcuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccggaggauucaacccggcggcggguccggccgugucggcgc
ggcggaucuuucccggggggaccgucccccgaccggcgaccggccgccgc
cgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcu
gggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcc
cccccggcagcagcacucgccgaaucccggggccgagggagcgagacccg
ucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcg
accgcucgggcggacuguccccagugcgccccgggcgggucgcgccgucg
ggcccggggggccacgcgcgcguccccggggacggcggagcgagcgcacg
gggucggcggcgacgucggcuacccacccgacccgucuugaaacacggac
caaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccgu
ggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggauccc
gaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgcc
gcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggu
gaacuaugccugggcagggcgaagccagaggaaacucugguggagguccg
uagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaa
agacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucagg
auagcuggcgcucucgcagacccgaacgcaguuuuauccgguaaagcgaa
ugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuua
aauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcga
gugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaac
cgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaa
agguguugguugauauagacagcaggacgguggccauggaagucggaauc
cgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaa
uggauggcgcuggagcgucgggcccauacccggccgucgccggcagucga
gaguggacgggagcgcgcggacgcuacgccgcgacgaguaggagggccgc
ugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcag
gugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggc
cgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucg
guccugagagaugggcgagcgccguuccgaagggacgggcgauggccucc
guugcccucggccgaucgaaagggagucggguucagauccccgaauccgg
agcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgauccc
ggagaagccggcgggagccccggggagaguucucuuuucuuugugaaggg
cagggcgcccuggaauggguucgccccgagagaggggcccgugccuugga
aagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaa
auccgggggagaggguguaaaucucgcgccgggccguacccauauccgca
gcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaa
gggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaa
gggcuggguagcagccgacuuagaacuggugcggaccaggggaauccgac
uguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcg
augugauuucugcccagugcucugaaugucaaagugaagaaauucaauga
agcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaau
gccucgucaucuaauuagugacgcgcaugaauggaugaacgagauuccca
cugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuugg
cggaaucagcggggaaagaagacccuguugagcuugacucuagucuggca
cggugaagagacaugagagguguagaauaagugggaggcccgggccgccg
gugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggg
gggcgagccccgaggggcucucgcuucuggcgccaagcgcccggcgccgg
gcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgg
uacaccugucaaacgguaacgcagguguccuaaggcgagcucagggagga
cagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuu
ucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccu
uuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacugg
cuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaug
ucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguu
cacccacuaauagggaacgugagcuggguuuagaccgucgugagacaggu
uaguuuuacccuacugaugauguguuguugccaugguaauccugcucagu
acgagaggaaccgcagguucagacauuugguguaugugcuuggcugagga
gccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaa
gucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgg
uuggccucggauagccggucccccgccgggguccggugcggagugcccuu
cguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgu
cacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacga
ccugcuucugggucgggguuucguacguagcagagcagcucccucgcugc
gaucuauugaaagucagcccucgacacaaggguuugu |
.........................<<<<<<.....<<....>>......
>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....
>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>...
..>>>>>..<<<<<<<<<<...<<<<<<<<.<......<<<<<<<<....
<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>
>>..>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>
>>>>.....<<<<<..((((((>>>>>..>>>..................
................<<....>>...............<<<<....>>>
>..................................<<<<<<<<..<<<.<
....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<..<<<<...
<<<<<.<<<..<<<.>>>>>>>>>>>..>>>>.>>>>...>>>>>>>>>>
>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<.
..<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>
>>>>.>>>........>>>>>>..>>>>>>>>>>>...............
.....<<<<<<.<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<
<<<<<<<<<<<<.<<<<....>>>>.>>>>>.>>>>>.>>>>>>>>>>.>
>>...>>>>>>>>.>>..<<<<<<<<..>>>>>>.>>....>>>>>>...
...>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<
<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....
>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<
..<<<..((((.(((.>>>..>>>....>>>>>.<<<<<<<<<.<<<<..
....>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<
.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>.
..<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<....
...>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>
>.><<.<<<<<<<..............<<<.<<<<<<<<<...<<<....
<<<..<.<<<..<<<<<<.<<...>>.>>>>>>>>>.>..>>>..>.>>.
..>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>
>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>
>>...<<<<<<<...<<<(((.......<<<<<......<..........
<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>
>>.........<<......>>...>>>>>...>>>>>>>>>>>>>.....
.....))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<......
.....))).))))..............>>>>>>>>>....>>>>>>...<
<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>
........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<
<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<
<<<<...<<....<<<....>>>..........<<.<<<<<<<.<...>.
>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<
.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<
<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<
<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>...
..<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>........
.>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<...
...>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.
<<...............<<<<<....<....>.....>>>>><<.<<<<<
<<<<<<.....>>>>>..>>>>>>.>>............<<<<<<<<<..
<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>
>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>....
.>>>.>>>>..>>>>><<<<<<.......>>>>>>........<......
.....<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.
....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>
....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<
<.<<<<<<<<<<......................................
......................>>>>>>>>>>...<<<<<.....<<<<.
.<<.<<<<<......>>>>>>>..............<<<<<<<<..>>>>
>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>
>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.
......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<
.......>>>>.>>>><<<<....>>>>>>)))].....<<<<<<<..<<
<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<
.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......
<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<......
...>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>
>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.....
............>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>
>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>
>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<..
..<<<........<<<<<.<<<......>>>.>>>>>.......>>>...
<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>.
.>>>..............>>>>..>>>>>>>>><<<<<............
........<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>
...>>>>....>>....>>>>.>>>.>>..>>>>>.. |
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| PDB | 8g60 mRNA decoding in human is kinetically and structurally distinct from bacteria. |
| Resolution | 2.54 Å |
Binding residue
(original residue number in PDB) | V2 N3 P5 R8 R9 F11 K13 G16 K17 H18 Y26 K28 G29 D31 S32 Y34 A35 Q36 G37 R39 R40 R43 K44 G47 Y48 G50 Q51 X53 P54 I55 F56 R57 K58 K59 A60 K61 T63 K64 K65 V67 R69 K80 R81 M82 A84 K86 R87 C88 K89 K97 K98 K100 |
Binding residue
(residue number reindexed from 1) | V1 N2 P4 R7 R8 F10 K12 G15 K16 H17 Y25 K27 G28 D30 S31 Y33 A34 Q35 G36 R38 R39 R42 K43 G46 Y47 G49 Q50 X52 P53 I54 F55 R56 K57 K58 A59 K60 T62 K63 K64 V66 R68 K79 R80 M81 A83 K85 R86 C87 K88 K96 K97 K99 |
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| Enzyme Commision number |
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