Structure of PDB 8rxx Chain Lj Binding Site BS01

Receptor Information
>8rxx Chain Lj (length=81) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKGTTSMGQRHGRTHILCRRCGRNSYHVQWERCAACAYPRASRRRYNWSV
KAIKRRRTGTGRCRYLKVVNRRIANHFKTPK
Ligand information
>8rxx Chain L1 (length=1657) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggca
caaauaucauugugugguuggugcaggaguggcgaaauucaagcgaaaag
caaacccguugcugaauacaacccuucaugugaguauugagccaaagaag
guguuagcccauugagccauaaaccugagcgccucaugaacaagcgagua
gcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaag
uuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaag
uuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugaca
aagacaauggaaguaccuccauuucaacggccagaaccagcccuacugca
uuauccugucggggaucaaaauccggcgggcaacgaagugcaagaaucuu
gggucuuggugaaaugagcggaguauuugagcugcgcacggcggccgcac
gcacugguuucuucuccgugaugcuccauguuggcgauggaaauggggug
cccccacccgucuugaaacacggaccaaggagucaaacagacgcgcaagg
gaggagauaugguugccaguacuucucucguacugaaagggagaugcaaa
augcaucuguggugugcacacgucaaauccguuugauuugcccaacaccg
accggcccuccguggguugcguuggagugugccuguuuggacccgaaagg
uggugaacuaugccugaacaaggugaagcccggggaaacccagguggagg
ccuguagcgaugcugacgugcaaaucgcucguaugauuuggguaucggag
cgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuucccu
caggauagcuggugcuaguagaaguauugugcgguaaagcaaaugauuag
agggaccuauucucaaacuuuaaaugugcaaacaaaccgugccuuagcca
acugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuuc
gguaagcggagcaggcgaugcggaaugaaccgcuuagggauauguggcgu
caaaacuuaugggcucauucucgauacgugaaaaggguguugguggauaa
auccaccggccccgaaaauggaugacgcuuaagcccaauuagugauugcc
cauuauuccuuugguaagggcggaaacaaauggagaaaguguagcccuuc
cgauguagauguggccuggagguuaggacgaagcuuauggcgugagccua
agauggaccggccucuagugcagaucuugguuggcguagcaaagaucuaa
cggagauauacucaacaugcaacguuggauacuggagcggggaaggauuu
cgugccaacggcacucguacacgaguuguucggaaacugagcacaacguu
auaucguuuuguuaggaaagugaaggugugucggcggagcuguucgacug
ugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaauugca
uguggga
......................<<<<<......<......>.......>>
>>.>.........<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
............<<<<...<<<<<<<<.<<<<<......<<<......<<
<<.......>>>>.....<<........>>......>>>.<<.......(
(.....>>)).....>>>>>...>>>..>>>>>.>>>>............
<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>
>....................................<<....>>.....
...........<<<<....>>>>...........................
.......<<<..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<<
<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>.........
>>>>..>>>>........<<<<<.....<<<<<<.<<.<<<<.>>>>...
>>.>.>>>.>>..>>>>>.....<<<<...>>>>>>....>>>>>>>>>>
>..>>>.<<<<........>>>><<<<<<...<<<<<<<<.<<<<<..<<
<..<<<.<............>>>>..>>>...<<....>>..<<<<<...
..>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>><
<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>>.<<.<...<<
<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....
>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<
.......>>......>>>>>>......>.>>...<<<<<....<.<<<..
..>>>.><<<<<<<<<.....<<...<<<<<<<...<<<....<<...<.
<<<..>>>.>...>>..>>.>...>>>>>>>.....<<<.<<<<<.<<..
...>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<<
<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<((
(......<..<<<<........<...........<<<.<<<<<<<<<<..
>>>>>>>>>>>>>..........))).>....>>>>.>.........>>>
...>>>>>>><<<<.<<<<<...........>>>>.........>>>>>>
>>>....>>>>>....<<<<<<<<.........<<<..<<<....>>>.>
>>.......>>>>>>>>........>>>>>>..............<<<<<
<<....................>>>>>>>....................<
<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<..
....>>>>............<.......<<...<......>...>>....
.>.....>.>>..........<<<<.........>>....>>.>>.....
.......
Receptor-Ligand Complex Structure
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PDB8rxx Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		K3 G4 T5 T6 S7 Q10 R11 H12 G13 R14 T15 H16 R24 S26 H28 Q30 R33 A35 R41 R44 R45 R46 Y47 N48 W49 S50 V51 K52 R56 R57 R58 T59 N71 K79 T80
Binding residue
(residue number reindexed from 1)		K2 G3 T4 T5 S6 Q9 R10 H11 G12 R13 T14 H15 R23 S25 H27 Q29 R32 A34 R40 R43 R44 R45 Y46 N47 W48 S49 V50 K51 R55 R56 R57 T58 N70 K78 T79
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8rxx, PDBe:8rxx, PDBj:8rxx
PDBsum8rxx
PubMed38722744
UniProtE9AEH2

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