Structure of PDB 8oj0 Chain Lg Binding Site BS01

Receptor Information
>8oj0 Chain Lg (length=114) Species: 2665953 (Homo sapiens environmental sample) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPG
RLRGVRAVRPKVLMRLSKTKKHVSRAYGGSMCAKCVRDRIKRAFLIEEQK
IVVKVLKAQAQSQK
Ligand information
>8oj0 Chain 5 (length=3474) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacau
guggcguacggaagacccgcuccccggcggggggcccaaguccuucugau
cgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgc
cgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagc
gggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauaguca
acaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaag
agggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcc
cggaggauucaacccggcggcggguccggccgugccggcgaccggccgcc
gccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacgg
cugggaaggcccggcggggaagguggcucgggggcccccgaguguuacag
cccccccggcagcagcacucgccgaaucccggggccgagggagcgagacc
cgucgccgcgcucuccccccggggggccgggccaccccucccacggcgcg
accgcucggggcggacuguccccagugcgccccgggcgggucgcgccguc
gggcccggggggccacgcgcgcgucccccgggggacggcggagcgagcgc
acggggucggcggcgacgucggcuacccacccgacccgucuugaaacacg
gaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgc
cguggcgcaaugaaggugaaggccggcgccggccgaggugggaucccgag
gccucuccaguccgccgagggcgcaccaccggcccgucucgcgggaggug
gagcacgagcgcacguguuaggacccgaaagauggugaacuaugccuggg
cagggcgaagccagaggaaacucugguggagguccguagcgguccugacg
ugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaacc
aucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucu
cgcagacccgacgcaguuuuauccgguaaagcgaaugauuagaggucuug
gggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcc
cggcucgcuggcguggagccgggcguggaaugcgagugccuagugggcca
cuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaa
ggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugaua
uagacagcgccgaaucaacuagcccugaaaauggauggcgcuggagcguc
gggcccauacccggccgucgccggcagucgagaguggacgggagccccgc
ggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagc
cuagggcgcgggcccggguggagccgccgcaggugcagaucuugguggua
guagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuc
caugugaacagcaguugaacaugggucagucgguccugagagaugggcga
gcgccguuccgaagggacgggcgcccucggccgaucgaaagggagucggg
uucagauccccgaauccggagcggagaugggcgccgcgaggcguccagug
cgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguu
cucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgaga
gaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugag
cucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccg
ggccguacccauauccgcagcaggucuccaaggugaacagccucuggcau
guuggaacaauguagguaagggaagucggcaagccggauccguaacuucg
ggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugc
ggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggccc
gcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaa
agugaagaaauucaaugaagcgcggguaaacggcgggaguacucucuuaa
gguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaa
cgagauucccacugucccuaccuacuauccagcgaaaccacagccaaggg
aacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacu
cuagucuggcacggugaagagacaugagagguguagaauaagugggaggc
ccgccggugaaauaccacuacucugauguuuuuucacugacccggugagg
cgggggggcgaucucgcuucuggcgccaagcgcccggccgcggccgggcg
cgacccgcuccggggacagugccagguggggaguuugacuggggcgguac
accugucaaacgguaacgcagguguccuaaggcgagcucagggaggacag
aaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuuca
guacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuu
ggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuu
guggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucg
gcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucac
ccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuag
uuuuacccuacugaugauguguuguugccaugguaauccugcucaguacg
agaggaaccgcagguucagacauuugguguaugugcuuggcugaggagcc
aauggggcgaagcuaccaucugugggauuaugacugaacgccucuaaguc
agaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguug
gccucggauagccgguccccgggguccggugcggagugcccuucguccug
ggaaacggggcgcggcuggaaaggcggccgcccccucgcccgucacgcac
cgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuu
cugggucgggguuucguacguagcagagcagcgcugcgaucuauugaaag
ucagcccucgacacaaggguuugu
.........................<<<<<<.....<......>......
>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....
>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>...
..>>>>>..<<<<<<<<<<...<<<<<<.<<<<<<<<....<<<<.....
.>>>>.....((......<<<.....))>>>...>.>>>>>>>.....>>
>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....
<<<<<..((((((>>>>>..>>>...........................
.......<<....>>...............<<<<....>>>>........
..........................<<<<<<<<..<<<.<<...<<<<<
<<<.<<<.....<<<<<<<<<<<..<<<<<<<...>>>>...>>>>>>>>
>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<
<...<<..<<<..<.<<<<......<<<<<<<<..>>>>>>>>.......
>>>>.>.>>>........>>>>>>..>>>>>>>>>>>.............
.......<<<<<<.<<<<<..>>>>>.<<<<<<.<<<<.<<<<<<<<<<<
<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>>>>>>>>.
>>>...>>>>>>>>.>>..<<<<<<<<<..>>>>>>>.>>....>>>>>>
.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>
><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>..
...>>>...<<....>>...<<<<<<..>>>>>>..<<<<<...<<<..<
<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<....>>>>>>
>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<
..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<..
......>>>>.>>>....>>>>>>>>>...<<.......>>......>>>
>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<.
............<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<
<<<.<<...>>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<
<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<
.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...
<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.
......<..>...>>>>>>>>>>>>>..........))).>>...>>>>>
..>>>...>>>>>>><<<<<<.<<<..........)))).))))......
.........>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<
<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<..
...<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<
<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<..
..>>>..........<<.<<<..>>>>>......>>....>>>..<<<<<
........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<
<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..
[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>....
.>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>
>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>
>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>..
..<<<<.....<<<<<<<.<<...............<<<<<....<<..>
>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>.....
.......<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<
.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<...
..<<<<....>>>>.....>>>.>>>>..>>>>><<<<<..>>>>>....
....<...........<<<<<.......>>>>>.....>.....>>....
>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<..
......>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<
<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<...........<..<<....
..............>>..>.>>>>.>>>>>>>>>>>>...<<<<<.....
<<<<..<<.<..>>>..............<<<<<<<<<<..>>>>>>>>>
>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..
<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<....
...>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<...
....>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..
)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.
<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<
<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........
>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>..
..>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<........
.........>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>
>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>
>....>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<
<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<
<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>...
...........>>>>..>>>>>>>>><<<<<.<.............>...
.<<.<<<<<<<.<<.....<<<<.<..<<<<..>>>>..>>>>>....>>
....>>>>.>>>.>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8oj0 UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER
Resolution3.3 Å
Binding residue
(original residue number in PDB)
V2 R4 L5 T6 Y7 R8 R9 R10 L11 S12 Y13 T15 S17 R21 R24 T25 P26 N28 Y34 K36 K37 K40 P42 K43 A45 V48 R54 G55 R57 R60 P61 K62 R66 S68 K69 T70 K72 H73 V74 S75 R76 Y78 G79 R90 R93 A94 I97 E98 Q100 K101 Q112 K115
Binding residue
(residue number reindexed from 1)
V1 R3 L4 T5 Y6 R7 R8 R9 L10 S11 Y12 T14 S16 R20 R23 T24 P25 N27 Y33 K35 K36 K39 P41 K42 A44 V47 R53 G54 R56 R59 P60 K61 R65 S67 K68 T69 K71 H72 V73 S74 R75 Y77 G78 R89 R92 A93 I96 E97 Q99 K100 Q111 K114
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8oj0, PDBe:8oj0, PDBj:8oj0
PDBsum8oj0
PubMed38383785
UniProtA0A6J3FY29

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