Structure of PDB 7z3o Chain Lf Binding Site BS01

Receptor Information

>7z3o Chain Lf (length=107) Species: 759272 (Thermochaetoides thermophila DSM 1495)

PSEAGHRLYVKGRHLSYQRGRRNTHPKTSLIKIEGVDDTAAANFYLGKRV
AYVYRAQKEVRGTKIRVIWGKITRPHGNSGVVRAKFTHPLPARSFGASVR
IMLYPSS

Ligand information

>7z3o Chain 1 (length=3191)

guugaccucggaucagguaggaggacccgcugaacuuaagcauaucaaua
agcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaag
cggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuugg
agaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgcc
acagagggugagagccccguauaguuggaagccaagccuguguaaagcuc
cuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaau
uucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagu
gaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaa
uuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucaucc
gguguucucaccggugcacuccgccgggcucaggccagcaucgguucugg
cggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcc
cuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugc
uggcguaauggucaccagcgacccgucuugaaacacggaccaaggaguca
agguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaagug
aacguaggugagagcuucggcgcaucaucgaccgauccugauguauucgg
auggauuugaguaggagcguuaagccuuggacccgaaagauggugaacua
ugcuuggauagggugaagccagaggaaacucugguggaggcucgcagcgg
uucugacgugcaaaucgaucgucaaaucugagcaugggggcgaaagacua
aucgaaccaucuaguagcugguuaccgccgaaguuucccucaggauagca
gugucgaccuucaguuuuaugagguaaagcgaaugauuagggacucgggg
gcgauuuuuagccuucauccauucucaaacuuuaaauauguaagaagccc
uuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggcc
auuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguua
aggugccggaguggacgcucaucagacaccacaaaaggcguuaguacauc
uugacagcaggacgguggccauggaagucggaauccgcuaaggacugugu
aacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaag
cgucccacccauaccccgcccucaggguagaaacgaugcccugaggagua
ggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaa
cggccucuagugcagaucuuggugguaguagcaaauacuucaaugagaac
uugaaggaccgaaguggggaaagguuccaugugaacagcgguuggacaug
gguuagucgauccuaagccauagggaaguuccguuucaaaggggcacucg
ugccccguguggcgaaagggaagccgguuaauauuccggcaccuggaugu
ggguuuugcgcggcaacgcaacugaacgcggagacgacggcgggggcccc
gggcagaguucucuuuucuucuuaacggucuaucacccuggaaacaguuu
gucuggagauaggguuuaauggccggaagagcccgacacuucugucgggu
ccggugcgcucucgacgucccuugaaaauccgcgggagggaauaauucuc
acgccaggucguacucauaaccgcagcagguccccaaggugaacagccuc
ugguugauagaacaauguagauaagggaagucggcaaaauagauccguaa
cuucgggaaaaggauuggcucuaaggguugggcacguugcggcgugcggu
uaacaaccaacuuagaacugguacggacagggggaaucugacugucuaau
uaaaacauagcauugcgauggccagaaagugguguugacgcaaugugauu
ucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggg
uaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucguc
aucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccu
aucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaauca
gcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaa
agacauaggagcuccuauuguuuuuuuacuuauucaaugaagcggggcug
gacuugcguccaacuucuggaguuaagguccuucgcgggccgacccgggu
ugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaa
ccauaacgcagguguccuaaggggggcucauggagaacagaaaucuccag
uagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauac
aaaccaugaaaguguggccuaucgauccuuuagucccucgaaauuugagg
cuagaggugccagaaaaguuaccacagggauaacuggcuuguggcggcca
agcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccua
ucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauag
ggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccua
cugaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcu
gauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaag
cuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugcc
agaacgcgacgauacuacccgcacguuguagacguauaagaauaggcucc
ggccucguauccuagcaggcgauuccuccgccggccucgaaguggccguc
gguaauucgcguauugcaauuuagacacgcgcgggaucaaauccuuugca
gacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguu
guuacgaucugcugaggguaagcccuccuucgccuagauuu

.........................<<<<<<.....<......>......
>>>>>.>.........<<....>>..<<<<<......<<.....>>....
.>>>>>..[[[..<<.......<<.<<<....>>>.>>.......>>...
.<<<<<.<<<<<<<<<..<<<<<<...<....<<<<......>>>>.((.
.....<<<.....))>>>....>...>>.>>>>..>>>>....>>>>>>>
>.>>........<<<<<<<........>>>>>>>.....(((((..<<<<
<<)))))..]]]..................................<<..
..>>...............<<<<....>>>>...................
...............<<<<.<<<<<<.....<<.<<<<<<<<<<....<<
<<<<....>>>>>>.....>>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<
<<<<<<.....<.<<<<<<<<......<<<<<....>>>>>.......>>
>>>>>>....>.>>>>>>>>>>>>>>>........<<...>>.....>>>
>>>>.....>>>>>>.>>>>..<<<<........>>>><<<<<<....<<
<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.
......<<<<<..<<<..>>>...>>>>>.<<<<<<<<...<<....>>.
..>>>.>>>.>>....>>>>.>>>>>>>>..<<.<...<<<<<<.....<
<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<.
.<..<<........>>.>.>>>....>>>>>>>>>...<<.......>>.
.....>>>>>>......>.>>...<<<<<....<.<<<....>>>.><<<
<<<<<<.....<<.<<<<<<<.....<<<....<<<....<<<...<<<<
<<........>>>>>>.>>>....>>>..>>.>.....>>>>>...<<<<
.<<<<.<......>>>>>.>>>>.....>>>>...>>>>>>>.>>..<<<
<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..
.<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.
......<<<<<.<<<...<<.........>>...>>>.........<<..
....>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>
>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....
>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>
>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......
>>>>>><<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>
>....((<<<<<<...<<<...<<<....>>>........<<<<<.....
.>>>>>....>>>....>>...<<<<<........>>>>>))<<<<.<<<
<.<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<
<<<.<<<<.......>>>>.><...<<<<<....<<<<<<....<<<...
..>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>
>>>>...>>>>>>>.>>>>.........>>>>>>.........>>>...>
>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.
.>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....
<<..>>.....>>>>><<.<<<<<<<<<<<.<<<<<<<..>>>>>>>...
...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.....
....>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<
<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>
>..>>>>><<<<<<.......>>>>>>........<...........<<<
<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>
>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[
[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<
<<<<<.<<<<..>>>>..>>>>>>>>>>>...<<<<<.....<<<<..<<
<<<....>>>>>..............<<<<<.....>>>>>..>>>>..>
>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<....
.......>>>>>>..<<...<<<<<<....<<<<<<.......>>>>>>.
....<<...(((>>.....>>>>>>...<<<.<<<<<.......>>>>.>
>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))
))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<..
.<<.......>>...>>>>>>...>>.>.>.......<<<<<..<<<<<.
.<.<<<<<<<......>>>>>>..>.>.<<<.........>>>.....>>
>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.
]]]]]....<<<<<<<..<<<<.<.<<<<<.................>>>
>>.><<<<<...<<<<....<<<<<<<<<<....>>>>>..>>>>>...>
>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>
>....>>>>>>>.....<<<<<.<..<<<......<<.......<<<<..
>>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>
>>....>>>>..............>>>.>.>>>>>...<<<<<<<.....
........>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......
>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7z3o Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): P2 S3 E4 H7 R8 Y10 K12 R20 G21 R22 R23 H26 K28 Y55 Q58 K59 R62 G63 T64 I66 W70 K72 R75 H77 N79 S80 R84 H89 P90 L91 P92 R94 S99
• Binding residue (residue number reindexed from 1): P1 S2 E3 H6 R7 Y9 K11 R19 G20 R21 R22 H25 K27 Y54 Q57 K58 R61 G62 T63 I65 W69 K71 R74 H76 N78 S79 R83 H88 P89 L90 P91 R93 S98

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0042273 ribosomal large subunit biogenesis

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7z3o, PDBe:7z3o, PDBj:7z3o
• PDBsum: 7z3o
• PubMed: 37081320
• UniProt: G0SCL3