Structure of PDB 8rxh Chain Ld Binding Site BS01

Receptor Information
>8rxh Chain Ld (length=97) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSKVDTINAKLQLVMKSGKYVLGTQQALTTLRQGRSKLVVIANNCPPIRR
AEVEYYCTLSKTPIHHYSGNNLDLGTACGKHFRTCVLSVTNVGDSDI
Ligand information
>8rxh Chain L2 (length=1155) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaaaaaauugccaacuca
gaacugcuuacggcggggaauccaacuguauaauuaaaacauagguuugu
gaugcauccaagugguguauaucgcaaacugauuucugcccagugcucug
aaugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaa
cuaugacucucuuaagguagccaaaugccucgucuuccaauuagagacgc
gcaugaauggauuaaugagauucccucugucccgaguuacuaucuagcga
aacgacagucaagggaacggacuugaagggcuaagcggggaaagaagacc
cuguugaguuugacuccagucuggcucugugcggcgacaucugaggcucg
gaacguugcuucacuuaucgaaugaagagaccaauggguuuagcguaguc
uucgggcuaugcaccgucuagguuugggaguccccuguggguacccaacc
gugcuguaaacugaaccaacgggauugcaguuccggagucuuguuucgag
acaucugccagauggggaguuuggcuggggcggcauaucuguuacacgac
aacgcagguguccuaaggcgagcucagugggaacagaaaucucacguaga
acacaagcguaaaagcuugcuugauuaacgauuuccaguacgaaucgaga
cugcgaaagcaaggccagcgauccuuugcgaagaauaggaaauaugaaca
aaucauaccagaggugucagaauaauuaccacagggauaacuggcuugug
gcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcu
cuuccuaaccuagcgccgcagaagacgcuaaggguuggauuguucaccca
cugacagggaacgugagcuggguuuagaccgucgugagacagguugguuu
uacccuacuuagcuggaaauugcgagaaaaagauuauccgugcaaagcgg
acgucgggucguugggccuggcgagcgguggguaguacaugguacgcuca
ucacc
........................<<......>>......<<<<.....>
>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<
<.....<..>......>>>>><<.<<<<<<<<<<<....>>>>>..>>>>
>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<
....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<..
..<<<....<<<<......>>>>....>>>.>>>>..>>>>><<<<<<..
.....>>>>>>........<...........<<<<<.......>>>>>..
...>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>....
........<<<<<........>>>>>..<<<<<<<..<<<.<<......<
<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<.<<<.<<.>>.>
>>..>>>>>>.>>>...<<<<<.....<<<<....<<.....<<<<<<<<
....>>>>>>>>.>>.....<<<<.<<...<<.<..>.>>...>>.>>>>
...................<<<<<......>>>>>..>>>>...>>>>>.
......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<........
...>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....
<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>
.<<<....>>>.>>.........<<<<<..............<<<<....
...>>>>.>>>>>..........>>>>..>>>>>>.......<<.<.<.<
<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.
<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>
.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>
>..>>>.>>>>>>>.......................<<<<.....>>>>
.<<<<<<<<<....>>>>>>>>>.<.<<<<<<<.<<<<...>>>>>>>>>
>>.>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8rxh Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.93 Å
Binding residue
(original residue number in PDB)		N49 C50
Binding residue
(residue number reindexed from 1)		N44 C45
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8rxh, PDBe:8rxh, PDBj:8rxh
PDBsum8rxh
PubMed38722744
UniProtE9AEK1

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